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Mediators of Inflammation
Volume 2014, Article ID 468285, 13 pages
http://dx.doi.org/10.1155/2014/468285
Research Article

The Impact of Staphylococcus aureus-Associated Molecular Patterns on Staphylococcal Superantigen-Induced Toxic Shock Syndrome and Pneumonia

1Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
2Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
3Division of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA
4Department of Immunology and Division of Infectious Diseases, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA

Received 30 January 2014; Revised 25 March 2014; Accepted 29 March 2014; Published 12 June 2014

Academic Editor: Ronald Gladue

Copyright © 2014 Ashenafi Y. Tilahun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Splenic mononuclear cells from HLA-DR3 transgenic mice were cultured with medium, HKSA (108 bacteria/ml), SEB (1μg/ml) or SEB+HKSA. 24 hours later, the cells were harvested, washed and expression of HLA-DR3 and CD86 on CD11c+ was analyzed by flow cytometry. Charts depict mean fluorescent intensity (MFI). Each bar represents mean ± SE from 2 different experiments.

  1. Supplementary Material