Proteomic Analysis of Lung Tissue in a Rat Acute Lung Injury Model: Identification of PRDX1 as a Promoter of Inflammation

<table>The establishment of the<i> P. aeruginosa-</i> (PA-) induced acute lung injury rat model. (a) Representative hematoxylin-eosin-stained lung tissue from the rats. Rats subjected to<i> P. aeruginosa</i> showed evidence of extensive lung injury with hemorrhage, inflammatory cell infiltration, and interstitial and alveolar edema compared with control conditions. Lung injury score (b), the lung W/D ratio (c), BALF TNF-<i>α</i>, and IL-1<i>β</i> ((d) and (e)) concentration were significantly increased in<i> P. aeruginosa</i> ALI rats as compared to control rats. <svg height="11.125" id="M29" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 36.237499 11.125" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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Mediators of Inflammation

fig1

Figure 1

Figure 1: Proteomic Analysis of Lung Tissue in a Rat Acute Lung Injury Model: Identification of PRDX1 as a Promoter of Inflammation 