Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice

Table 2

Electrocardiogram after treatment with pyridostigmine bromide. Electrocardiographical parameters (expressed as mean ± S.E.M.) collected at the 6th month of observation and after one month of treatment (from the 5th to 6th month of infection) in noninoculated control (Con) or T. cruzi-inoculated (Chg) anesthetized C57BL/6j mice treated with pyridostigmine bromide (Pyrido) or vehicle (NT: nontreated animals).

	Con-NT	Con-Pyrido	Chg-NT	Chg-Pyrido
RR (ms)	137.56 ± 3.37	141.05 ± 5.38	152.54 ± 5.01*	152.98 ± 12.93
Pd (ms)	14.01 ± 1.53	13.38 ± 1.51	18.68 ± 0.52^*&#	14.63 ± 0.53
PR (ms)	37.93 ± 1.96	44.38 ± 2.51*	45.45 ± 2.22*	43.2 ± 0.99
QRSd (ms)	14.45 ± 1.39	13.47 ± 1.37	15.04 ± 0.53	14.5 ± 0.41
QT (ms)	17.77 ± 1.87	17.35 ± 1.38	22.47 ± 1.04^*#	18.21 ± 0.59
cQT (ms^1/2)	1.51 ± 0.51	1.49 ± 0.47	1.83 ± 0.09^*&#	1.51 ± 0.06

RR: RR interval; Pd: P wave duration; PR: PR interval; QRSd: QRS complex duration; QT: QT interval; cQT: corrected QT interval; versus Con-NT; ms: milliseconds; versus Chg-Pyrido; and versus Con-Pyrido.