Chemokine CXCL16 Expression Suppresses Migration and Invasiveness and Induces Apoptosis in Breast Cancer Cells

Figure 4

CXCL16 expression inhibited tumor development in vivo. Four groups of single cells (MDA-MB-231, LV-NC, LV-CXCL16, and MCF-7) were injected subcutaneously into mice and tumor growth was monitored. (a) CXCL16 overexpression led to a decrease in tumorigenesis. ^∗𝑃<0.05 compared with MCF-7. ^#𝑃<0.05 compared with MDA-MB-231. ^▼𝑃<0.01 compared with MCF-7. (b) CXCL16 overexpression reduced tumor volume and weight. ^#𝑃<0.05 compared with MDA-MB-231. ^▼𝑃<0.01 compared with MCF-7. ^∗𝑃<0.05 compared with MCF7.

(a)

(b)