Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention

Table 2

Baseline characteristics and IL-6 and IL-10 levels in a subgroup.

Variable	Low clopidogrel loading dose (300–450 mg); (𝑛=32)	High clopidogrel loading dose (600 mg); (𝑛=20)	P value
Age (yrs)	58.4±15.3	65.7±12.2	0.17
Male sex (%)	84.3	55.0	0.20
Hypertension (%)	37.5	40.0	0.53
Diabetes mellitus (%)	21.9	20.0	1.00
Hypercholesterolemia (%)	31.3	25.0	1.00
Current smoking (%)	50.0	35.0	0.76
Body mass index (kg/m^2)	26.8±4.7	24.7±4.8	0.17
Anterior infarction (%)	40.6	30.0	0.34
IL-6 (ng/L)
Admission	7.51 (5.13, 12.93)	5.86 (4.55, 8.08)	0.20
4–6 h after PPCI	10.31 (7.90, 14.89)	5.96 (5.18, 10.93)	0.02
12 h after PPCI	8.43 (6.88, 11.90)	8.52 (6.81, 13.84)	0.88
24 h after PPCI	7.79 (6.16, 11.15)	6.70 (5.72, 8.56)	0.24
7 d after PPCI	9.73 (6.40, 13.53)	8.13 (6.56, 12.11)	0.73
Peak value	13.44 (11.94, 19.90)	11.54 (8.94, 24.59)	0.24
IL-10 (ng/L)
Admission	18.53 (15.54, 22.73)	21.78 (20.74, 23.16)	0.11
4–6 h after PPCI	16.39 (11.24, 19.56)	20.64 (16.87, 22.57)	0.02
12 h after PPCI	18.73 (15.70, 20.99)	19.06 (15.36, 21.52)	0.86
24 h after PPCI	18.29 (15.05, 21.22)	20.72 (18.87, 22.55)	0.05
7 d after PPCI	17.66 (15.59, 20.86)	19.44 (16.77, 21.15)	0.50
Peak value	21.35 (20.00, 24.33)	22.71 (21.58, 24.60)	0.12

Values represent mean ± SD or median with 25 and 75 percentiles.
Note: CAD: coronary artery disease; PCI: percutaneous coronary intervention; hs-CRP: high-sensitive C-reactive protein; HDL-C: high density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol; IL-6: interleukin-6; IL-10: interleukin-10.