Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord

Figure 5

The effects of puerarin on CCI- and diabetes-induced proinflammatory cytokines overexpression (a) and NF-𝜅B overactivation ((b), (c), (d)) on the 11th day after CCI surgery, and on the 27th day after streptozotocin injection in rat spinal cord. Data are presented as mean ± SEM. CCI: chronic constriction injury; Cyt: cytoplasmic; Nuc: nuclear. ^∗∗∗𝑃<0.001, CCI and diabetes models versus control; ^#𝑃<0.05, ^##𝑃<0.01, ^###𝑃<0.001, puerarin versus CCI and diabetes models (one-way ANOVA with post hoc LSD 𝑡-test). Each group consisted of 6–10 rats.

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