Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis
Figure 1
(a) Enzymatic generation of citrulline from arginine catalyzed by peptidylarginine deiminase (PAD); (b) non-enzymatic formation of homocitrulline by carbamylation of lysine by cyanate; (c) products of reactions between tyrosine with reactive oxygen species (forming dityrosine), reactive nitrogen species (forming 3-nitrotyrosine) and reactive chlorine species forming 3-chlorotyrosine; (d) examples of AGEs formed including carboxymethyl arginine and pentosidine (formed between an arginine and lysine residue).
