Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2014, Article ID 518265, 8 pages
http://dx.doi.org/10.1155/2014/518265
Research Article

Production of the Growth Factors GM-CSF, G-CSF, and VEGF by Human Peripheral Blood Cells Induced with Metal Complexes of Human Serum γ-Globulin Formed with Copper or Zinc Ions

Laboratory of Cell to Cell Interactions, N.F. Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation, Gamaleya Street 18, Moscow 123098, Russia

Received 31 March 2014; Accepted 20 May 2014; Published 3 July 2014

Academic Editor: Fulvio D’Acquisto

Copyright © 2014 Sergey B. Cheknev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Kidd, “Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease,” Alternative Medicine Review, vol. 8, no. 3, pp. 223–246, 2003. View at Google Scholar · View at Scopus
  2. K. Z. Long and N. Nanthakumar, “Energetic and nutritional regulation of the adaptive immune response and trade-offs in ecological immunology,” The American Journal of Human Biology, vol. 16, no. 5, pp. 499–507, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Vasto, E. Mocchegiani, G. Candore et al., “Inflammation, genes and zinc in ageing and age-related diseases,” Biogerontology, vol. 7, no. 5-6, pp. 315–327, 2006. View at Google Scholar · View at Scopus
  4. J. C. Cyktor and J. Turner, “Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens,” Infection and Immunity, vol. 79, no. 8, pp. 2964–2973, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Sahoo, I. Ceballos-Olvera, L. del Barrio, and F. Re, “Role of the inflammasome, IL-1β, and IL-18 in bacterial infections,” TheScientificWorldJournal, vol. 11, pp. 2037–2050, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Cairo, S. Recalcati, A. Mantovani, and M. Locati, “Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype,” Trends in Immunology, vol. 32, no. 6, pp. 241–247, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Cope, G. Le Friec, J. Cardone, and C. Kemper, “The Th1 life cycle: molecular control of IFN-γ to IL-10 switching,” Trends in Immunology, vol. 32, no. 6, pp. 278–286, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Shi, C. H. Liu, A. I. Roberts et al., “Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don’t know,” Cell Research, vol. 16, no. 2, pp. 126–133, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. J. R. Tisoncik, M. J. Korth, C. P. Simmons, J. Farrar, T. R. Martin, and M. G. Katze, “Into the eye of the cytokine storm,” Microbiology and Molecular Biology Reviews, vol. 76, no. 1, pp. 16–32, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Bo, F. Wang, J. Zhu, J. Li, and X. Deng, “Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis,” Critical Care, vol. 15, no. 1, article R58, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Bovolenta, S. Gasperini, and M. A. Cassatella, “Granulocyte colony-stimulating factor induces the binding of stat1 and stat3 to the ifny response region within the promoter of the fcγri/cd64 gene in human neutrophils,” FEBS Letters, vol. 386, no. 2-3, pp. 239–242, 1996. View at Google Scholar · View at Scopus
  12. J. A. Hamilton and A. Achuthan, “Colony stimulating factors and myeloid cell biology in health and disease,” Trends in Immunology, vol. 34, no. 2, pp. 81–89, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. A.-K. Olsson, A. Dimberg, J. Kreuger, and L. Claesson-Welsh, “VEGF receptor signalling—in control of vascular function,” Nature Reviews Molecular Cell Biology, vol. 7, no. 5, pp. 359–371, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Bar-Yehuda, L. Madi, D. Barak et al., “Agonists to the A3 adenosine receptor induce G-CSF production via NF-κB activation: a new class of myeloprotective agents,” Experimental Hematology, vol. 30, no. 12, pp. 1390–1398, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. L. L. de Figueiredo, R. S. de Abreu E Lima, and E. M. Rego, “Granulocyte colony-stimulating factor and leukemogenesis,” Mediators of Inflammation, vol. 13, no. 3, pp. 145–150, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Krishnan, B. Arnone, and A. Buchman, “Intestinal growth factors: potential use in the treatment of inflammatory bowel disease and their role in mucosal healing,” Inflammatory Bowel Diseases, vol. 17, no. 1, pp. 410–422, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. S. J. Rubino, K. Geddes, and S. E. Girardin, “Innate IL-17 and IL-22 responses to enteric bacterial pathogens,” Trends in Immunology, vol. 33, no. 3, pp. 112–118, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. C. A. Sorgi, S. Rose, N. Court et al., “GM-CSF priming drives bone marrow-derived macrophages to a pro-inflammatory pattern and downmodulates PGE2 in response to TLR2 ligands,” PLoS ONE, vol. 7, no. 7, Article ID e40523, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Ferrara, “VEGF-A: a critical regulator of blood vessel growth,” European Cytokine Network, vol. 20, no. 4, pp. 158–163, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Neufeld, T. Cohen, S. Gengrinovitch, and Z. Poltorak, “Vascular endothelial growth factor (VEGF) and its receptors,” FASEB Journal, vol. 13, no. 1, pp. 9–22, 1999. View at Google Scholar · View at Scopus
  21. E. Shochat, V. Rom-Kedar, and L. A. Segel, “G-CSF control of neutrophils dynamics in the blood,” Bulletin of Mathematical Biology, vol. 69, no. 7, pp. 2299–2338, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Sulica, W. H. Chambers, M. Manciulea et al., “Divergent signal transduction pathways and effects on natural killer cell functions induced by interaction of Fc receptors with physiologic ligands or antireceptor antibodies,” Natural Immunity, vol. 14, no. 3, pp. 123–133, 1995. View at Google Scholar · View at Scopus
  23. C. E. van der Poel, R. M. Spaapen, J. G. J. van de Winkel, and J. H. W. Leusen, “Functional characteristics of the high affinity IgG receptor, FcγRI,” Journal of Immunology, vol. 186, no. 5, pp. 2699–2704, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Weber, H. Tian, N. van Rooijen, and L.-A. Pirofski, “A Serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibody requires Fcγ receptor III and macrophages to mediate protection against pneumococcal pneumonia in mice,” Infection and Immunity, vol. 80, no. 4, pp. 1314–1322, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Bitsaktsis, B. V. Iglesias, Y. Li et al., “Mucosal immunization with an unadjuvanted vaccine that targets Streptococcus pneumoniae PspA to human fcγ receptor type I protects against pneumococcal infection through complement- and lactoferrin-mediated bactericidal activity,” Infection and Immunity, vol. 80, no. 3, pp. 1166–1180, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. I. Anegon, M. C. Cuturi, G. Trinchieri, and B. Perussia, “Interaction of Fc receptor (CD16) ligands induces transcription of interleukin 2 receptor (CD25) and lymphokine genes and expression of their products in human natural killer cells,” Journal of Experimental Medicine, vol. 167, no. 2, pp. 452–472, 1988. View at Google Scholar · View at Scopus
  27. M. C. Cuturi, I. Anegon, F. Sherman et al., “Production of hematopoietic colony-stimulating factors by human natural killer cells,” Journal of Experimental Medicine, vol. 169, no. 2, pp. 569–583, 1989. View at Google Scholar · View at Scopus
  28. P. Lenz, J. E. Gessner, C. Sautes, and R. E. Schmidt, “Fcγ-receptor III (CD16) is involved in NK-B cell interaction,” Immunobiology, vol. 196, no. 4, pp. 387–398, 1996. View at Google Scholar · View at Scopus
  29. X. Li, J. G. Baskin, E. K. Mangan et al., “The unique cytoplasmic domain of human FcγRIIIA regulates receptor-mediated function,” Journal of Immunology, vol. 189, no. 9, pp. 4284–4294, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. S. B. Cheknev, E. E. Babaeva, A. E. Golub et al., “The effects of copper and zinc ions during their binding with human serum γ-globulin,” Medical Immunology, vol. 8, no. 5-6, pp. 615–622, 2006 (Russian). View at Google Scholar
  31. S. B. Cheknev, I. E. Efremova, E. A. Denisova, and E. N. Yushkovets, “Immuno-enzyme analysis of the γ-globulin which has bound metal ions, at the low samples concentrations,” Russian Journal of Immunology, vol. 2/11, no. 1, pp. 55–62, 2008 (Russian). View at Google Scholar
  32. S. B. Cheknev, E. A. Denisova, E. E. Babaeva et al., “Conformational state and antigen characteristics of human γ-globulin transformed with binding the copper and zinc cations,” Immunologiya, vol. 28, no. 5, pp. 274–280, 2007 (Russian). View at Google Scholar
  33. S. B. Cheknev, I. E. Efremova, L. S. Piskovskaya et al., “Metal complexes of human serum γ-globulin induce production of the early IL-2,” Russian Journal of Immunology, vol. 6/15, no. 2, pp. 147–154, 2012 (Russian). View at Google Scholar
  34. S. B. Cheknev, I. E. Efremova, A. S. Mezdrokhina, and A. A. Babajanz, “Evaluation of IL-6 production by human blood cells incubated with metal complexes of γ-globulin,” Medical Immunology, vol. 14, no. 6, pp. 483–488, 2012 (Russian). View at Google Scholar
  35. S. B. Cheknev, I. E. Efremova, L. S. Piskovskaya, E. N. Yushkovets, and A. A. Babajanz, “Production of early IL-1β induced by human serum γ-globulin metal complexes,” Bulletin of Experimental Biology and Medicine, vol. 154, no. 3, pp. 343–345, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. S. B. Cheknev, I. E. Efremova, M. A. Apresova, and A. A. Babajantz, “Induction of TNF-α production by metal complexes of γ-globulin fraction proteins and copper and zinc cations,” Bulletin of Experimental Biology and Medicine, vol. 154, no. 6, pp. 758–761, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. S. B. Cheknev, M. A. Apresova, I. E. Efremova, and A. A. Babajanz, “Production of IL-18 in presence of metal-γ-globulin complexes,” Medical Immunology, vol. 15, no. 1, pp. 13–20, 2013 (Russian). View at Google Scholar
  38. S. B. Cheknev, M. A. Apresova, I. E. Efremova et al., “Involvement of the γ-globulin metal complexes in regulation of the interleukin-10 production,” Immunologiya, vol. 34, no. 4, pp. 189–193, 2013 (Russian). View at Google Scholar
  39. R. Mallone, A. Funaro, M. Zubiaur et al., “Signaling through CD38 induces NK cell activation,” International Immunology, vol. 13, no. 4, pp. 397–409, 2001. View at Google Scholar · View at Scopus
  40. N. Ferrara and T. Davis-Smyth, “The biology of vascular endothelial growth factor,” Endocrine Reviews, vol. 18, no. 1, pp. 4–25, 1997. View at Publisher · View at Google Scholar · View at Scopus
  41. D. I. R. Holmes and I. Zachary, “The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease,” Genome Biology, vol. 6, no. 2, article 209, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Sibéril, R. Ménez, S. Jorieux et al., “Effect of zinc on human IgG1 and its FcγR interactions,” Immunology Letters, vol. 143, pp. 60–69, 2012. View at Google Scholar
  43. B. N. Thomas and L. U. Buxbaum, “FcγRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions,” Infection and Immunity, vol. 76, no. 2, pp. 623–631, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. P. J. Maglione, J. Xu, A. Casadevall, and J. Chan, “Fcγ receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection,” Journal of Immunology, vol. 180, no. 5, pp. 3329–3338, 2008. View at Google Scholar · View at Scopus
  45. P. J. Maglione and J. Chan, “How B cells shape the immune response against Mycobacterium tuberculosis,” European Journal of Immunology, vol. 39, no. 3, pp. 676–686, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. T. L. McGaha, M. C. I. Karlsson, and J. V. Ravetch, “FcγRIIB deficiency leads to autoimmunity and a defective response to apoptosis in MrL-MpJ mice,” Journal of Immunology, vol. 180, no. 8, pp. 5670–5679, 2008. View at Google Scholar · View at Scopus