Cardiac Fibroblasts Aggravate Viral Myocarditis: Cell Specific Coxsackievirus B3 Replication

Figure 6

Comparison of CVB3 replication in different cell types. Due to viral infection cardiac fibroblasts revealed 132-fold increase (83 × 10³ 11 × 10⁶ copies) of the viral (+) RNA strand between 6 and 24 hours leading to a severe virus replication, whereas in cardiomyocytes 14-fold increase (7.5 × 10³ 107 × 10³ copies) of the viral (+) RNA strand was measured. In macrophages, low virus concentration leads to weak virus replication (17 32 copies). High virus concentration leads to virus elimination but not to complete virus clearance (258 71 copies). The copy numbers of both CVB3 strands 6 hours and 24 hours after infection are given (6 h 24 h).