Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease

Figure 3

Diabetes downregulates endogenous anti-inflammatory protective pathways. (a) Diabetes (8 weeks after STZ administration) downregulated plasma netrin-1. ^∗𝑃<0.001 versus nondiabetic control. 𝑛=5. Netrin-1 in plasma was quantified by ELISA. (b) and (c) RT-PCR analysis of netrin-1 and UNC5B expression in control and 12-week diabetic mouse. Diabetes downregulated netrin-1 (C) and UNC5B (G) expression in the kidney. ^∗𝑃<0.001 versus control. 𝑛=5.

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(b)

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