Ticlopidine in Its Prodrug Form Is a Selective Inhibitor of Human NTPDase1
Figure 4
Influence of ticlopidine (100 μM or 1 mM) on the ATPase and ADPase activity of apyrase (a) and (100 μM) on human NPP1 and human NPP3 (b). The activity of apyrase without ticlopidine was and μmoles Pi/min·mg protein for ATP and ADP, respectively. Data are presented as the mean ± SD of 3 experiments carried out in triplicate. The 100% activities without ticlopidine with pNP-TMP as the substrate were and nmol p-nitrophenol/min·mg protein for NPP1 and NPP3, respectively. ; .
