Sphingosine-1-phosphate/S1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells

<table>The effect of silencing S1PR expression on S1P-induced migration in human BMSCs. (a)–(c) Cells were transfected with control siRNA or with siRNA targeted against S1PR1 (a), S1PR2 (b), or S1PR3 (c) for 48 h. Then S1PR1, S1PR2, or S1PR3 mRNA was evaluated by real-time RT-PCR. (d)–(f) Effect of silencing S1PR1, S1PR2, or S1PR3 expression on human BMSCs migration in response to S1P. Data are presented as the mean ± SD. <svg height="17.825001" id="M4" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 66.324997 17.825001" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, compared with control siRNA.</table>

Mediators of Inflammation

fig3

Figure 3

Figure 3: Sphingosine-1-phosphate/S1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells 