Interactions between Neutrophils, Th17 Cells, and Chemokines during the Initiation of Experimental Model of Multiple Sclerosis
Figure 4
Modulation of EAE by anti-CXCR2 or anti-IL23R antibodies. (a) Mean time to EAE onset and mean EAE score at day 2 of the attack, (b) accumulation of Th17 cells and neutrophils in the brain, and (c) BBB permeability. Accumulation of inflammatory cell subpopulations was analyzed at the second day of EAE using flow cytometry; BBB permeability was analyzed at the same time point using Evans blue dye as described in Materials and Methods. Data are presented as mean ± SEM. *.
