Aryl Hydrocarbon Receptor (AhR) Modulates Cockroach Allergen-Induced Immune Responses through Active TGFβ1 Release

Figure 3

AhR modulates cockroach allergen-induced TGFβ1 production. (a) TCDD can induce TGFβ1 secretion by fibroblasts and (b) cockroach allergen-induced TGFβ1 secretion by fibroblasts can be further enhanced by TCDD but inhibited by AhR antagonist CH122319 (c). (c) Cockroach allergen-induced TGFβ1 production and the inhibitory role of CH122319 were further confirmed when Bla g2 was used. Bars represent mean ± SEM of 3 independent experiments. *𝑃<0.05, **𝑃<0.01.

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