Aryl Hydrocarbon Receptor (AhR) Modulates Cockroach Allergen-Induced Immune Responses through Active TGFβ1 Release
AhR controls LTBP-1 expression in fibroblasts. (a-b) Fibroblasts were treated with TCDD at 0.1 nM and 1 nM for 2 to 48 hours; expression of LTBP1 (a) and LTBP-2 (b) was detected by RT-PCR. Each point represents mean ± SEM of at least 3 independent experiments. (c) WI38 cells were treated with LTBP1 siRNA, scramble RNA, or medium control for 24 h and then treated with 50 μg/mL CRE for 24 h; active form TGFβ1 in the supernatant was detect with ELISA.
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