Mediators of Inflammation / 2014 / Article / Fig 6

Research Article

Aryl Hydrocarbon Receptor (AhR) Modulates Cockroach Allergen-Induced Immune Responses through Active TGFβ1 Release

Figure 6

AhR controls LTBP-1 expression in fibroblasts. (a-b) Fibroblasts were treated with TCDD at 0.1 nM and 1 nM for 2 to 48 hours; expression of LTBP1 (a) and LTBP-2 (b) was detected by RT-PCR. Each point represents mean ± SEM of at least 3 independent experiments. (c) WI38 cells were treated with LTBP1 siRNA, scramble RNA, or medium control for 24 h and then treated with 50 μg/mL CRE for 24 h; active form TGFβ1 in the supernatant was detect with ELISA.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.