Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi
Table 1
Summary of the ECG records.
Days after challenge
Strain
Sinus arrhythmia mouse groups
values
G1
G2
G3
G1 × G2
G1 × G3
G2 × G3
80
Brazil
0/6
0/6
0/6
NS
NS
NS
150
Brazil
0/6
19/6
0/6
0.001
NS
0.001
240
Brazil
0/6
20/6
3/6
0.001
NS
0.026
80
Colombian
0/6
0/6
0/5
NS
NS
NS
150
Colombian
0/6
1/6
1/5
NS
NS
NS
240
Colombian
0/6
9/6
1/5
0.017
NS
0.093
Days after challenge
Strain
Atrioventricular block
values
G1
G2
G3
G1 × G2
G1 × G3
G2 × G3
80
Brazil
0/6
0/6
0/6
NS
NS
NS
150
Brazil
0/6
4/6
2/6
0.03
NS
NS
240
Brazil
0/6
59/6
7/6
0.001
0.004
0.003
80
Colombian
0/6
19/6
0/5
0.001
NS
NS
150
Colombian
0/6
14/6
6/5
0.001
0.002
NS
240
Colombian
0/6
39/6
10/5
0.001
0.002
NS
ECG record of mice genetically vaccinated and challenged as described in the legend of Figure 5(a). Values represent the number of episodes (sinus arrhythmia or atrioventricular block) recorded during one minute per total of mice analyzed and were compared by Fisher exact probability test.
