Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study

Table 3

Inflammatory markers in OSA and non-OSA obese children.

	Total (𝑛=204)	No-OSA (𝑛=129)	OSA (𝑛=75)	𝑃 value
IL-6 (pg/mL)	7.5±3.8	7.3±3.2	8±4.8	0.2
	[7–8.1]	[6.7–7.8]	[6.8–9.1]
IL-18 (pg/mL)	170.2±96.8	163.2±80.8	182.4±119.2	0.17
	[156.9–183.6]	[149.1–177.2]	[155.1–209.9]
PAI-1 (ng/mL)	3.3±1.2	3.2±1.2	3.6±1.3	0.01^†
	[3.1–3.5]	[2.9–3.4]	[3.3–3.9]
MCP-1 (pg/mL)	35.1±16.9	33.2±15.2	38.4±19.1	0.03^†
	[32.8–37.5]	[30.6–35.9]	[34–42.8]
Apelin C (ng/mL)	127.9±118.9	125.9±80.8	131.3±165.8	0.7
	[111.5–144.3]	[111.9–140]	[93.1–169.4]
Adropin (ng/mL)	0.8±0.3	0.8±0.3	0.87±0.32	0.1
	[0.79–0.87]	[0.75–0.85]	[0.79–0.94]
Adiponectin (μg/mL)	28.1±13.3	26.8±12.1	30.3±14.9	0.07
	[26.2–29.9]	[24.6–28.9]	[26.8–33.7]
MMP-9 (μg/mL)	0.9±0.6	0.9±0.5	1±0.8	0.1
	[0.85–1]	[0.8–0.97]	[0.85–1.2]
Osteocrin (ng/mL)	8.5±12.6	7.8±7.2	9.7±18.5	0.3
	[6.7–10.2]	[6.5–9.1]	[5.5–14]
Leptin (ng/mL)	19.1±8.1	18.5±8.2	20±8	0.2
	[17.9–20.2]	[17.1–19.9]	[18.1–21.8]
IS	0±4.3	−0.5±3.4	0.8±5.4	0.04^†
	[−0.49–4.9]	[−1.1–0.13]	[−0.43–2.1]

∗Data presented as mean ± SD [CI_95%]. †Statistically significant difference; IS: inflammatory cumulative score.