LPS-Challenged TNFα Production, Prostaglandin Secretion, and TNFα/TNFRs Expression in the Endometrium of Domestic Cats in Estrus or Diestrus, and in Cats with Pyometra or Receiving Medroxyprogesterone Acetate
Figure 6
TNFR1 protein localization in endometria. Immunohistochemical (IHC) localization of TNFR1 in the endometria of cats collected at (a) estrus phase (E, ) and (b) diestrus phase (D, ) from (c) cats that had been treated with a P4 derivative analog, medroxyprogesterone acetate (MPA, ); or (d) cats presenting the clinical symptoms of pyometra (PYO, ). (a) In females at estrus, only weak TNFR1 signals are localized in the glandular and surface epithelium; (b) in females at diestrus, positive staining is localized in the glandular and surface epithelium, similar to (c) MPA females; (d) in PYO females, strong signals are mostly localized in both the surface and the glandular epithelium. Surface epithelium: white arrowheads; glandular epithelium: white arrows; endometrial stroma: black arrows.
