Diethylcarbamazine Reduces Chronic Inflammation and Fibrosis in Carbon Tetrachloride- (CCl₄-) Induced Liver Injury in Mice

Figure 3

Ultrathin sections of hepatocytes. (a) Control group; (b), (c) and (d) CCl₄ group; (e) and (f) DEC + CCl₄ group. Note that the chronic cell injury exhibits swollen mitochondria, several vacuoles (V) and lyses of chromatin, characteristic of a necrosis process (head arrows). Note also the collagen fibers (asterisk), rER dilatation (black arrows), and an autophagosome containing mitochondria (star). Mitochondria (M), glycogen (G), nucleus (N), nucleolus (Nu), rough endoplasmic reticulum (rER), and peroxisomes (white arrows). Bar: 1 and 2 μm.

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