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Mediators of Inflammation
Volume 2014, Article ID 701013, 9 pages
Review Article

New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease

1Service d’Hématologie Clinique, Centre Hospitalier et Universitaire (CHU), CHU Hôtel-Dieu, Place Alexis Ricordeau, 44093 Nantes, France
2Université Pierre et Marie Curie, INSERM, UMRs 938, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France
3Service d’Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, APHP, 75012 Paris, France

Received 14 December 2013; Accepted 1 February 2014; Published 11 March 2014

Academic Editor: Vinod K. Mishra

Copyright © 2014 Florent Malard and Mohamad Mohty. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Allogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-threatening malignant and nonmalignant hematologic disorders. Graft-versus-host disease (GVHD) remains a major source of morbidity and mortality following allo-SCT, which limits the use of this treatment in a broader spectrum of patients. Early diagnostic of GVHD is essential to initiate treatment as soon as possible. Unfortunately, the diagnosis of GVHD may be difficult to establish, because of the nonspecific nature of the associated symptoms and of the numerous differential diagnosis. This is particularly true regarding gastrointestinal (GI) acute GVHD. In the recent years many progress has been made in medical imaging test and endoscopic techniques. The interest of these different techniques in the diagnosis of GI acute GVHD has been evaluated in several studies. With this background we review the contributions, limitations, and future prospect of these techniques in the diagnosis of GI acute GVHD.