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Mediators of Inflammation
Volume 2014, Article ID 703175, 10 pages
http://dx.doi.org/10.1155/2014/703175
Research Article

Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin

1Department of Pathophysiology, School of Medicine, Comenius University, Sasinkova 4, 81372 Bratislava, Slovakia
23rd Clinic of Medicine, School of Medicine, Comenius University, 83305 Bratislava, Slovakia
3Institute of Experimental Endocrinology, Slovak Academy of Sciences, 83305 Bratislava, Slovakia
4Center of Excellence NOREG, 81372 Bratislava, Slovakia
5Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 81371 Bratislava, Slovakia
6Institute of Molecular Biomedicine, School of Medicine, Comenius University, 81372 Bratislava, Slovakia
7Department of Physiology, School of Medicine, Charles University, 50038 Hradec Kralove 1, Czech Republic

Received 10 January 2014; Revised 27 May 2014; Accepted 29 May 2014; Published 6 July 2014

Academic Editor: Russel J. Reiter

Copyright © 2014 Fedor Simko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. J. Reiter, L. C. Manchester, L. Fuentes-Broto, and D. Tan, “Cardiac hypertrophy and remodelling: pathophysiological consequences and protective effects of melatonin,” Journal of Hypertension, vol. 28, no. 1, pp. S7–S12, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Simko and O. Pechanova, “Remodelling of the heart and vessels in experimental hypertension: advances in protection,” Journal of Hypertension, vol. 28, supplement 1, pp. S1–S6, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Simko, J. Matuskova, I. Luptak et al., “Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension,” Life Sciences, vol. 74, no. 10, pp. 1211–1224, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Simko, V. Pelouch, J. Torok et al., “Protein remodeling of the heart ventricles in hereditary hypertriglyceridemic rat: effect of ace-inhibition,” Journal of Biomedical Science, vol. 12, no. 1, pp. 103–111, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. C. A. Mandarim-de-Lacerda and L. M. M. Pereira, “Effect of telmisartan on preexistent cardiac and renal lesions in spontaneously hypertensive mature rats,” Histology and Histopathology, vol. 19, no. 3, pp. 727–733, 2004. View at Google Scholar · View at Scopus
  6. F. Simko, “Statins: a perspective for left ventricular hypertrophy treatment,” European Journal of Clinical Investigation, vol. 37, no. 9, pp. 681–691, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Kyselovic, P. Krenek, M. Wibo, and T. Godfraind, “Effects of amlodipine and lacidipine on cardiac remodelling and renin production in salt-loaded stroke-prone hypertensive rats,” The British Journal of Pharmacology, vol. 134, no. 7, pp. 1516–1522, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Simko, R. J. Reiter, O. Pechanova, and L. Paulis, “Experimental models of melatonin-deficient hypertension,” Frontiers in Bioscience, vol. 18, no. 2, pp. 616–625, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Ozturk, M. Ozler, Y. G. Kurt et al., “Efficacy of melatonin, mercaptoethylguanidine and 1400W in doxorubicin- and trastuzumab-induced cardiotoxicity,” Journal of Pineal Research, vol. 50, no. 1, pp. 89–96, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Grossini, C. Molinari, F. Uberti, D. A. S. G. Mary, G. Vacca, and P. P. Caimmi, “Intracoronary melatonin increases coronary blood flow and cardiac function through β-adrenoreceptors, MT1/MT2 receptors, and nitric oxide in anesthetized pigs,” Journal of Pineal Research, vol. 51, no. 2, pp. 246–257, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Samimi-Fard, P. Abreu-Gonzalez, A. Dominguez-Rodriguez, and A. Jimenez-Sosa, “A case-control study of melatonin receptor type 1A polymorphism and acute myocardial infarction in a Spanish population,” Journal of Pineal Research, vol. 51, no. 4, pp. 400–404, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Zeman and I. Herichova, “Melatonin and clock genes expression in the cardiovascular system,” Frontiers in Bioscience, vol. 1, no. 5, pp. 743–753, 2013. View at Google Scholar
  13. F. Simko and L. Paulis, “Melatonin as a potential antihypertensive treatment,” Journal of Pineal Research, vol. 42, no. 4, pp. 319–322, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Tengattini, R. J. Reiter, D. Tan, M. P. Terron, L. F. Rodella, and R. Rezzani, “Cardiovascular diseases: protective effects of melatonin,” Journal of Pineal Research, vol. 44, no. 1, pp. 16–25, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Dominguez-Rodriguez, P. Abreu-Gonzalez, J. J. Sanchez-Sanchez, J. C. Kaski, and R. J. Reiter, “Melatonin and circadian biology in human cardiovascular disease,” Journal of Pineal Research, vol. 49, no. 1, pp. 14–22, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Paulis and F. Šimko, “Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind,” Physiological Research, vol. 56, no. 6, pp. 671–684, 2007. View at Google Scholar · View at Scopus
  17. R. A. Hoffman and R. J. Reiter, “Rapid pinealectomy in hamsters and other small rodents,” The Anatomical Record, vol. 153, no. 1, pp. 19–21, 1965. View at Google Scholar
  18. S. C. Cunnane, M. S. Manku, M. Oka, and D. F. Horrobin, “Enhanced vascular reactivity to various vasoconstrictor agents following pinealectomy in the rat: role of melatonin,” Canadian Journal of Physiology and Pharmacology, vol. 58, no. 3, pp. 287–293, 1980. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Zanoboni and W. Zanoboni-Muciaccia, “Experimental hypertension in pinealectomized rats,” Life Sciences, vol. 6, no. 21, pp. 2327–2331, 1967. View at Publisher · View at Google Scholar · View at Scopus
  20. G. M. Brown, A. Bar-Or, D. Grossi, S. Kashur, and E. Johannson, “Urinary 6-sulphatoxymelatonin, an index of pineal function in the rat,” Journal of Pineal Research, vol. 10, no. 3, pp. 141–147, 1991. View at Publisher · View at Google Scholar · View at Scopus
  21. D. X. Tan, L. D. Chen, B. Poeggeler et al., “Melatonin: a potent, endogenous hydroxyl radical scavenger,” Endocrine Journal, vol. 1, pp. 157–160, 1993. View at Google Scholar
  22. R. J. Reiter, D. X. Tan, M. P. Terron, L. J. Flores, and Z. Czarnocki, “Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions,” Acta Biochimica Polonica, vol. 54, no. 1, pp. 1–9, 2007. View at Google Scholar · View at Scopus
  23. A. Galano, D. X. Tan, and R. J. Reiter, “Melatonin as a natural ally against oxidative stress: a physicochemical examination,” Journal of Pineal Research, vol. 51, no. 1, pp. 1–16, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. R. J. Reiter and D. X. Tan, “Melatonin: a multitasking molecule,” Progress in Brain Research, vol. 181, pp. 127–151, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Rezzani, E. Porteri, C. de Ciuceis et al., “Effects of melatonin and pycnogenol on small artery structure and function in spontaneously hypertensive rats,” Hypertension, vol. 55, no. 6, pp. 1373–1380, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. R. J. Reiter, D. Tan, and A. Korkmaz, “The circadian melatonin rhythm and its modulation: possible impact on hypertension,” Journal of Hypertension, vol. 27, supplement 6, pp. S17–S20, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Dominguez-Rodriguez, P. Abreu-Gonzalez, and R. J. Reiter, “Melatonin and cardiovascular disease: myth or reality?” Revista Espanola de Cardiologia, vol. 65, no. 3, pp. 215–218, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Paulis, J. Matuskova, M. Adamcova et al., “Regression of left ventricular hypertrophy and aortic remodelling in NO-deficient hypertensive rats: effect of L-arginine and spironolactone,” Acta Physiologica, vol. 194, no. 1, pp. 45–55, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Benova, C. Viczenczova, J. Radosinska et al., “Melatonin attenuates hypertension-related proarrhythmic myocardial maladaptation of connexin-43 and propensity of the heart to lethalarrhythmias,” Canadian Journal of Physiology and Pharmacology, vol. 91, no. 8, pp. 633–639, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Dominguez-Rodriguez, P. Abreu-Gonzalez, M. Garcia-Gonzalez, and R. J. Reiter, “Prognostic value of nocturnal melatonin levels as a novel marker in patients with ST-segment elevation myocardial infarction,” The American Journal of Cardiology, vol. 97, no. 8, pp. 1162–1164, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Dominguez-Rodriguez, P. Abreu-Gonzalez, and R. J. Reiter, “Clinical aspects of melatonin in the acute coronary syndrome,” Current Vascular Pharmacology, vol. 7, no. 3, pp. 367–373, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Dominguez-Rodriguez, P. Abreu-Gonzalez, E. Arroyo-Ucar, and R. J. Reiter, “Decreased level of melatonin in serum predicts left ventricular remodelling after acute myocardial infarction,” Journal of Pineal Research, vol. 53, no. 3, pp. 319–323, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Dominguez-Rodriguez, P. Abreu-Gonzalez, E. Arroyo-Ucar, P. Avanzas, and R. J. Reiter, “Global left ventricular longitudinal strain is associated with decreased melatonin levels in patients with acute myocardial infarction: a two-dimensional speckle tracking study,” Biomarkers, vol. 18, no. 4, pp. 310–313, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Dominguez-Rodriguez, P. Abreu-Gonzalez, M. J. Garcia-Gonzalez, J. C. Kaski, R. J. Reiter, and A. Jimenez-Sosa, “A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty. The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial: study design and rationale,” Contemporary Clinical Trials, vol. 28, no. 4, pp. 532–539, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Dominguez-Rodriguez, P. Abreu-Gonzalez, and R. J. Reiter, “Melatonin and cardioprotection in the acute myocardial infarction: a promising cardioprotective agent,” International Journal of Cardiology, vol. 158, no. 2, pp. 309–310, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Repova-Bednarova, S. Aziriova, and J. Hrenak, “Effect of captopril and melatonin on fibrotic rebuilding of the aorta in 24 hour light-induced hypertension,” Physiological Research, vol. 62, supplement 1, pp. S135–S141, 2013. View at Google Scholar
  37. I. Bernátová, O. Pecháňová, V. Pelouch, and F. Šimko, “Regression of chronic L-NAME-treatment-induced left ventricular hypertrophy: effect of captopril,” Journal of Molecular and Cellular Cardiology, vol. 32, no. 2, pp. 177–185, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. F. Simko, O. Pechanova, V. Pelouch et al., “Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats,” Journal of Hypertension, vol. 27, supplement 6, pp. S5–S10, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. V. Pelouch, M. Milerova, B. Ostadal, M. Samánek, and B. Hucín, “Protein profiling of human atrial and ventricular musculature: the effect of normoxaemia and hypoxaemia in congenital heart diseases,” Physiological Research, vol. 42, no. 4, pp. 235–242, 1993. View at Google Scholar · View at Scopus
  40. V. Pelouch, M. Milerova, B. Ostadal, B. Hucin, and M. Samanek, “Differences between atrial and ventricular protein profiling in children with congenital heart disease,” Molecular and Cellular Biochemistry, vol. 147, no. 1–4, pp. 43–49, 1995. View at Publisher · View at Google Scholar · View at Scopus
  41. G. K. Reddy and C. S. Enwemeka, “A simplified method for the analysis of hydroxyproline in biological tissues,” Clinical Biochemistry, vol. 29, no. 3, pp. 225–229, 1996. View at Publisher · View at Google Scholar · View at Scopus
  42. G. Munch, R. Keis, A. Wessels et al., “Determination of advanced glycation end products in serum by fluorescence spectroscopy and competitive ELISA1,” European Journal of Clinical Chemistry and Clinical Biochemistry, vol. 35, no. 9, pp. 669–677, 1997. View at Google Scholar · View at Scopus
  43. A. D. Bhatwadekar and V. S. Ghole, “Rapid method for the preparation of an AGE-BSA standard calibrator using thermal glycation,” Journal of Clinical Laboratory Analysis, vol. 19, no. 1, pp. 11–15, 2005. View at Google Scholar
  44. V. Witko-Sarsat, M. Friedlander, C. Capeillère-Blandin et al., “Advanced oxidation protein products as a novel marker of oxidative stress in uremia,” Kidney International, vol. 49, no. 5, pp. 1304–1313, 1996. View at Publisher · View at Google Scholar · View at Scopus
  45. J. K. Lang, K. Gohil, and L. Packer, “Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions,” Analytical Biochemistry, vol. 157, no. 1, pp. 106–116, 1986. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Kucharská, A. Gvozdjáková, and F. Šimko, “Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension,” Physiological Research, vol. 56, supplement 2, pp. S49–S54, 2007. View at Google Scholar · View at Scopus
  47. M. Zeman, K. Dulková, V. Bada, and I. Herichová, “Plasma melatonin concentrations in hypertensive patients with the dipping and non-dipping blood pressure profile,” Life Sciences, vol. 76, no. 16, pp. 1795–1803, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. R. M. Buijs and A. Kalsbeek, “Hypothalamic integration of central and peripheral clocks,” Nature Reviews Neuroscience, vol. 2, no. 7, pp. 521–526, 2001. View at Publisher · View at Google Scholar · View at Scopus
  49. F. A. J. L. Scheer, G. A. van Montfrans, E. J. W. van Someren, G. Mairuhu, and R. M. Buijs, “Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension,” Hypertension, vol. 43, no. 2, pp. 192–197, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. M. Jonas, D. Garfinkel, N. Zisapel, M. Laudon, and E. Grossman, “Impaired nocturnal melatonin secretion in non-dipper hypertensive patients,” Blood Pressure, vol. 12, no. 1, pp. 19–24, 2003. View at Google Scholar · View at Scopus
  51. F. Simko, O. Pechanova, V. Pelouch et al., “Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril,” Journal of Hypertension, vol. 28, supplement 1, pp. S13–S18, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. O. Pechánová, J. Zicha, L. Paulis et al., “The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension,” European Journal of Pharmacology, vol. 561, no. 1–3, pp. 129–136, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. L. Paulis, O. Pechanova, J. Zicha et al., “Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats,” Journal of Hypertension, vol. 27, supplement 6, pp. S11–S16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. K. T. Weber, “From inflammation to fibrosis: a stiff stretch of highway,” Hypertension, vol. 43, no. 4, pp. 716–719, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. F. Simko and J. Simko, “The potential role of nitric oxide in the hypertrophic growth of the left ventricle,” Physiological Research, vol. 49, no. 1, pp. 37–46, 2000. View at Google Scholar · View at Scopus
  56. F. Simko, “Is NO the king? Pathophysiological benefit with uncertain clinical impact [editorial],” Physiological Research, vol. 56, supplement 2, pp. S1–S6, 2007. View at Google Scholar
  57. H. Karppanen, S. Lahovaara, P. Männistö, and H. Vapaatalo, “Plasma renin activity and in vitro synthesis of aldosterone by the adrenal glands of rats with spontaneous, renal, or pinealectomy induced hypertension,” Acta Physiologica Scandinavica, vol. 94, no. 2, pp. 184–188, 1975. View at Publisher · View at Google Scholar · View at Scopus
  58. V. Milosievic, S. Trifunovic, M. Sekulic et al., “Chronic exposure to constant light affects morphology and secretion of adrenal zona fascikulata cells in female rats,” General Physiology and Biophysics, vol. 24, no. 3, pp. 299–309, 2005. View at Google Scholar
  59. H. Li, Y. Kang, L. Yu, H. Xu, and H. Zhao, “Melatonin reduces blood pressure in rats with stress-induced hypertension viaGABAA receptors,” Clinical and Experimental Pharmacology and Physiology, vol. 36, no. 4, pp. 436–440, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. R. J. Reiter, D. X. Tan, L. C. Manchester, M. Pilar Terron, L. J. Flores, and S. Koppisepi, “Medical implications of melatonin: receptor-mediated and receptor-independent actions,” Advances in Medical Sciences, vol. 52, pp. 11–28, 2007. View at Google Scholar · View at Scopus
  61. M. Koziróg, A. R. Poliwczak, P. Duchnowicz, M. Koter-Michalak, J. Sikora, and M. Broncel, “Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome,” Journal of Pineal Research, vol. 50, no. 3, pp. 261–266, 2011. View at Publisher · View at Google Scholar · View at Scopus
  62. F. Simko, J. Simko, and M. Fabryova, “ACE-inhibition and angiotensin II receptor blockers in chronic heart failure: pathophysiological consideration of the unresolved battle,” Cardiovascular Drugs and Therapy, vol. 17, no. 3, pp. 287–290, 2003. View at Publisher · View at Google Scholar · View at Scopus