Anti-Inflammatory Effects of IKK Inhibitor XII, Thymulin, and Fat-Soluble Antioxidants in LPS-Treated Mice
Plasma cytokine values in inflammation-bearing mice treated with antioxidant-rich diet and IKK Inhibitor XII. Seven mouse groups were used: inflammation-bearing (IB) mice; three groups of IB mice pretreated with inhibitor at concentration 5 mg/kg (Inh5), 10 mg/kg (Inh10), or 20 (Inh20) mg/kg; IB mice pretreated with antioxidant-rich diet; IB mice pretreated with antioxidant-rich diet plus inhibitor; and untreated controls. Each group consisted of 4 mice, which was examined individually. Each value is average mean ± SD from four independent experiments; the measurements were made for each individual mouse in six duplicates. Data are expressed in pg/mL of plasma. Significantly different from control, . ∧Significantly different from LPS-group, . #Significantly different from Inh(5) or Inh (10) plus LPS-group, .