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Mediators of Inflammation
Volume 2014, Article ID 728673, 10 pages
http://dx.doi.org/10.1155/2014/728673
Review Article

The Roles of CD147 and/or Cyclophilin A in Kidney Diseases

1Department of Critical Care Medicine, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China
2Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Beijing 100050, China

Received 2 July 2014; Revised 30 October 2014; Accepted 26 November 2014; Published 17 December 2014

Academic Editor: Dennis D. Taub

Copyright © 2014 Xin Qu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.