Anti-Inflammatory Functions of Protein C Require RAGE and ICAM-1 in a Stimulus-Dependent Manner
Figure 5
Effect of PC treatment on survival during LPS-induced endotoxemia in wild-type, RAGE , and Icam-1 mice. Lethal endotoxemia was induced by Escherichia coli LPS (serotype 055:B5, 40 mg/kg i.p.) and treated with PC (100 U/kg, i.p.) or human albumin (8 mg/mL) as controls at 0.5, 8, and 24 h after LPS challenge. Survival is shown in Kaplan-Meier plots for the respective treatments in Icam-1 mice (a) and RAGE mice (b) and compared to WT mice. Significant differences by log-rank test were set at and indicated by asterisks.
