Anti-Inflammatory Functions of Protein C Require RAGE and ICAM-1 in a Stimulus-Dependent Manner
Figure 8
Effect of PC on endothelial ICAM-1 expression. Surface ICAM-1 expression was measured on freshly prepared (a) and TNFα-stimulated (25 ng TNFα/mL, 4 h) (b) endothelial cells with or without PC preincubation (5 U/106 leukocytes, 3 h) and compared to respective isotype controls. Mean fluorescence intensities are presented as mean ± SEM from at least three mice per group. Significant differences () to isotype and anti-ICAM-1 + PC are indicated by the asterisks.
