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Mediators of Inflammation
Volume 2014 (2014), Article ID 750860, 8 pages
http://dx.doi.org/10.1155/2014/750860
Research Article

Early Effects of a Hypocaloric, Mediterranean Diet on Laboratory Parameters in Obese Individuals

1Department of Health Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy
2Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy
3Department of Clinical and Experimental Medicine, Magna Græcia University of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy

Received 18 December 2013; Accepted 19 January 2014; Published 4 March 2014

Academic Editor: Massimiliano M. Corsi Romanelli

Copyright © 2014 Marta Greco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Calorie restriction is a common strategy for weight loss in obese individuals. However, little is known about the impact of moderate hypocaloric diets on obesity-related laboratory parameters in a short-term period. Aim of this study was to evaluate the variation of laboratory biomarkers in obese individuals following a Mediterranean, hypocaloric (1400–1600 Kcal/die) diet. 23 obese, pharmacologically untreated patients were enrolled and subjected to the determination of anthropometric variables and blood collection at baseline, 1 and 4 months after diet initiation. After 4 months of calorie restriction, we observed a significant decrease in body weight and BMI (both ), insulin ( ), HOMA-IR ( ), leptin ( ), and LDH ( ) and an increase in EGF ( ). All these parameters, except LDH, varied significantly already at 1 month after diet initiation. Also, lower levels of insulin ( ), leptin ( ), and EGF ( ) were associated with a greater (>5%) weight loss. Collectively, our data support a precocious improvement of insulin and leptin sensitivity after a modest calorie restriction and weight reduction. Moreover, EGF and LDH may represent novel markers of obesity, which deserve further investigations.