Impaired Resolution of Inflammation in the Endoglin Heterozygous Mouse Model of Chronic Colitis

Table 1

Expression of cytokines and chemokines in the distal colon during DSS-induced colitis in Eng ^+/+ and Eng ^+/− mice.

Cytokine	Cytokine levels (pg/mg tissue protein)
	Eng ^+/+			Eng ^+/−
	Day 0	Days 7–9	Days 18–23	Day 0	Days 7–9	Days 18–23
CXCL1	10.9±0.6	791±196^∗	49±8.8^∗	11.6±2.3	1614±261^∗†	138±75^∗
G-CSF	1.3±0.3	3319±1028^∗	35±8.0^∗	1.2±0.3	5740±1209^∗	100±49^∗
IL-6	2.3±0.2	1516±569^∗	35±10^∗	2.6±0.2	2608±735^∗	220±142^∗
CCL11	45±3.5	514±77^∗	99±6.8^∗	58±9.2	638±45^∗	119±20^#
Il-1𝛽	13.0±2.3	66±16^∗	20±1.7	13.5±0.7	51±13^∗	42±20
IL-10	9.2±2.0	37±13^∗	24±5.1	8.0±2.3	24±2.7^∗	18±3.7
TNF𝛼	1.9±0.7	12.0±2.7^∗	2.4±0.9	1.8±0.9	5.8±0.8^∗†	3.0±0.9
IFN𝛾	3.4±0.6	20±10.6	6.0±1.4	2.7±0.1	4.8±1.6	9.2±4.3
IL-17	1.1±0.3	7.0±2.6	2.6±0.6	1.0±0.2	2.0±0.6	5.3±2.1
M-CSF	1.5±0.6	9.4±4.3	1.2±0.4	1.5±0.7	25±15	0.8±0.2
GM-CSF	8.0±1.5	8.4±2.2	6.6±2.5	8.6±3.5	8.3±2.5	3.7±1.8
IL-12p40	6.1±1.5	4.0±1.2	3.8±0.9	6.2±1.4	1.8±0.7	2.0±0.6
IL-12p70	0.8±0.4	1.1±0.4	0.3±0.2	1.2±1.0	1.0±0.4	0.4±0.4
IL-4	1.4±0.1	1.7±0.1	1.4±0.1	1.6±0.1	1.4±0.1	1.3±0.1

Results represent mean ± SEM (for both genotypes, 𝑁=4 mice for day 0, N = 7-8 mice for days 7–9 and 18–23). ^∗𝑃<0.05 versus corresponding day 0, ^#𝑃=0.06 versus corresponding day 0, and ^†𝑃<0.05 versus corresponding Eng ^+/+.