CD80 and CD86 Costimulatory Molecules Differentially Regulate OT-II CD4⁺ T Lymphocyte Proliferation and Cytokine Response in Cocultures with Antigen-Presenting Cells Derived from Pregnant and Pseudopregnant Mice

Figure 3

Changes in cytokine profile detected in cocultures of OVA-specific T cells with splenic APCs isolated from pseudopregnant (a) or mated (b) female mice after blockade of costimulatory molecules CD80 and CD86. Data were presented as increase/decrease of concentration in comparison to appropriate isotype control-treated cultures (mean ± SEM). 𝑁=10 samples per group. Student’s 𝑡-test (parametric) or Wilcoxon (nonparametric) test, *𝑃<0.05; **𝑃<0.01.

(a)  

(b)