Mediators of Inflammation

Research Article

CD80 and CD86 Costimulatory Molecules Differentially Regulate OT-II CD4+ T Lymphocyte Proliferation and Cytokine Response in Cocultures with Antigen-Presenting Cells Derived from Pregnant and Pseudopregnant Mice

Table 1

Summary of influence of blockade of CD80 and CD86 costimulatory molecules on proliferation of OT-II CD4+ T lymphocytes and cytokine concentration in pseudopregnant and pregnant mice.
 PseudopregnancyPregnancy
 CD11c+F4/80+CD11b+CD11c+F4/80+CD11b+
 808680868086808680868086
IFN-g  ↑↓        
IL-2  ↓  ↓  ↓   
IL-4↓ ↓ ↓   ↓ ↑ 
IL-10↓↓    ↓ ↓   
IL-12↓↓    ↓ ↓ ↑ 
TGF-b  ↓   ↓ ↓↓  
BrdU ↓↑↓ ↓ ↓ ↓ ↓
↑: increased proliferation or cytokine concentration, ↓: decreased proliferation or cytokine concentration.