Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2014 (2014), Article ID 790851, 8 pages
http://dx.doi.org/10.1155/2014/790851
Review Article

Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions

1Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th Floor, AOU Policlinico “G. Martino’’, Via C. Valeria Gazzi, 98125 Messina, Italy
2Department of Paediatric, Gynaecological, Microbiological and Biomedical Sciences, University of Messina, Via C. Valeria Gazzi, 98125 Messina, Italy

Received 6 June 2014; Revised 6 August 2014; Accepted 6 August 2014; Published 24 August 2014

Academic Editor: Fabio Santos Lira

Copyright © 2014 Alessandra Bitto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Flavonoids, from Scutellaria baicalensis (Chinese skullcap) and Acacia catechu (black catechu), have been shown to exert a variety of therapeutic effects, including anti-inflammatory, antiviral, antibacterial, and anticancer activities. Flavocoxid is a mixed extract containing baicalin and catechin and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase enzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX) enzyme activity in vitro. Flavocoxid downregulates gene or protein expression of several inflammatory markers and exerts also strong antioxidant activity in several experimental models. Controlled clinical trials and a postmarketing study have clearly shown that flavocoxid is as effective as naproxen in managing the signs and symptoms of osteoarthritis of the knee and it has better upper gastrointestinal, renal, and respiratory safety profile than naproxen. Flavocoxid may therefore provide a potential therapeutic approach to the treatment of chronic inflammatory conditions.