Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease
Figure 7
Anti-TNF therapy ameliorates electrical abnormalities in chronically Trypanosoma cruzi-infected mice. C57BL/6 mice infected with 100 bt of the Colombian T. cruzi strain were treated from 120 to 150 dpi and analyzed at 150 dpi. (a) Representative ECG register segments of sex- and age-matched NI controls and T. cruzi-infected mice injected with saline or anti-TNF, at 150 dpi. (b) Group data for the ECG records showing the heart rate (beats per minute, bpm), variation in the PR, QTc, and QRS intervals. (c) Summary of the group data from NI and T. cruzi-infected mice (injected with saline or anti-TNF) showing the frequency of mice presenting ART, AVB2 and afflicted by any ECG alterations. and , T. cruzi-infected mice (saline injected or anti-TNF treated) compared to NI controls. # and ##, anti-TNF-treated compared to saline-injected T. cruzi-infected mice. Bar represents the mean ± SD of the studied group (10 to 15 mice). These data represent three independent experiments.
