Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease
Figure 8
Anti-TNF therapy decreases fibronectin expression in the cardiac tissue of chronically Trypanosoma cruzi-infected mice. C57BL/6 mice infected with 100 bt of the Colombian T. cruzi strain were treated from 120 to 150 dpi and analyzed at 150 dpi. Representative heart sections from each experimental group analyzed by immunohistochemical staining to detect FN are shown. Data are expressed as percentage of FN-stained area (%). and , T. cruzi-infected mice (saline injected or anti-TNF treated) compared to NI controls. ###, anti-TNF-treated compared to saline-injected T. cruzi-infected mice. Bar represents the mean ± SD of the studied group (3 to 5 mice). These data represent three independent experiments.
