Mediators of Inflammation

Review Article

Mushrooms: A Potential Natural Source of Anti-Inflammatory Compounds for Medical Applications

Table 1

Anti-inflammatory compounds of mushrooms.
Mushroom speciesBiomaterial source Extracting solvent Bioactive compound References
Agaricus blazei WM1Polysaccharides[51]
A. bisporus WM3Pyrogallol, hydroxybenzoic acid derivatives, flavonoids.[91]
FB4Polysaccharide (fucogalactan)[65]
A. subrufescens WM2Polysaccharide (proteoglucan)[55]
Agrocybe aegerita FB3Fatty acids [88]
A. cylindracea FB2Agrocybin[98]
Albatrellus caeruleoporus FB3Phenolic compound (Grifolinones A, B) [93, 94]
Amanita muscaria FB 2, 3, 4Crude extract[99]
Boletus edulis WM 3polysaccharides, [91]
Cantharellus cibarius WM3Pyrogallol, flavonoids, polysaccharides [91]
C. tubaeformis WM2Polysaccharides[74]
Cordyceps militaris SC/FB4Crude extract [100]
C. pruinosa FB3Crude extract [101]
Caripia montagnei FB 3Polysaccharides (Glucans)[63]
Cyathus africanus SC5Diterpenoid[76]
C. hookeri SC5Diterpenoid [77]
Daldinia childiae FBN.M.Benzophenones (daldinals A-C)[92]
Elaphomyces granulatus FB4Syringaldehyde, syringic acid[19, 96]
Flammulina velutipes WM4Polysaccharides [72]
Fomitopsis pinicola SC4Polysaccharides[102]
Grifola frondosa SC5, 6Agaricoglycerides [97]
SC3, 5, Ergosterol (1-oleoyl-2-linoleoyl-3-palmitoylglycerol)[103]
Ganoderma lucidum FB4Triterpene[78]
FB 4Lucidenic acid, ganoderic acid [81]
Geastrum saccatum FB4Polysaccharides (β-glucans)[104]
 FB2, 4, 5Crude extract [82]
Inonotus obliquus FB8, 5Ergosterols, lanosterol, inotodiol, trametenolic acid [84]
FB3Crude extract [83]
 FB4Crude extract [105]
Lactarius deliciosus WM3Pyrogallol, flavonoids[91]
L. rufus FB2, 4Polysaccharides: (13), (16)-β-D-glucans[64]
Lentinus edodes FB2Heterogalactan (fucomannogalactan) with main chain of (1→6)-linked α-D-glactopyranosyl unit [66]
L. polychrous SC 4 Crude extract [67]
Lyophyllum decastes FB3Polysaccharides: (1–3) and (1–6) β-D-glucans [106]
Phellinus linteus FB9Polysaccharides (proteoglycan)[69]
FB4, 7, 9Crude extract[107]
Pholiota nameko WM4, 6, 10Polysaccharides [71]
Pleurotus pulmonarius FBN.M.Polysaccharides (1→3), (1→6)-linked β-glucan[60]
FB2, 4Polysaccharides (Glucan)[57]
Poria cocos SC 4Polysaccharides [108]
Termitomyces albuminosus SC/FB4Crude polysaccharide extract [68]
WM, whole mushroom; SC, submerged culture; FB, fruiting bodies.
Solvent: N.M., not mentioned; 1, chloroform; 2, water; 3, methanol; 4, ethanol; 5, ethyl acetate; 6, acetone; 7, n-hexane; 8, petroleum ether; 9, n-butanol; 10, acetyl ether.