Peptidases from Latex of Carica candamarcensis Upregulate COX-2 and IL-1 mRNA Transcripts against Salmonella enterica ser. Typhimurium-Mediated Inflammation

Table 1

Leukocyte cell counts in the bloodstream of Swiss mice pretreated with P1G10 6 h after injection of carrageenan or heat-killed S. Typhimurium into the peritoneal cavity.

	Total leukocytes (10^3 cells/mm^3)	Differential leukocyte cell counts (10^3 cells/mm^3)
		Eosinophil	Lymphocytes	Neutrophils	Monocytes	Basophils
P1G10 (i.p) + 0.5 mg carrageenan (i.p.)
PBS	5.90±1.30	0.0±0.0	3.58±1.10	2.23±0.53	0.09±0.04	0.0±0.0
1 mg/Kg	4.37±2.25	0.0±0.0	2.69±1.31	1.64±0.97	0.04±0.03	0.0±0.0
10 mg/kg	8.52±1.56^∗	0.0±0.0	4.44±1.22	4.02±0.45^∗	0.06±0.04	0.0±0.0
P1G10 (i.p.) + Heat-killed Salmonella (i.p.)
PBS	4.40±0.98	0.0±0.0	2.93±0.68	1.41±0.30	0.05±0.04	0.0±0.0
1 mg/Kg	4.32±1.54	0.0±0.0	3.10±1.07	1.17±0.48	0.05±0.03	0.0±0.0
10 mg/kg	6.72±0.66^∗	0.0±0.0	4.63±0.65^∗	2.01±0.59	0.08±0.06	0.0±0.0

∗Significant difference in comparison to PBS group (𝑃<0.05).