Chitosan Oligosaccharides Attenuate Ocular Inflammation in Rats with Experimental Autoimmune Anterior Uveitis
Effects of COS on the activation of NF-κB in the ICB at day 14. Evaluation of (a) IκB and (b) NF-κB p65 in each group using western blot analysis. The Y scale represents the ratio of the IκB or p65 blot density to the β-actin blot density ( for each group). (c) Immunohistochemical study of the expression of the NF-κB p65 subunit in retinas. The images represent three rats in each group. (d) The NF-κB/DNA binding activity in the ICB was measured using EMSA. “Fold change” was defined as optic density of the PBS-treated, low-dose, or high-dose COS group divided by optic density of the normal group ( for each group) (∗ compared with the PBS-treated group; # compared with the normal group; & compared with the low-dose group by Kruskal-Wallis test with post hoc Dunn test).