Maternal Plasma and Amniotic Fluid Chemokines Screening in Fetal Down Syndrome
Table 3
Concentrations of chemokines in amniotic fluid.
Group I: Down syndrome pregnancies
Group II: pregnancies without Down syndrome
value
Chemokines concentration (pg/mL) Mean ± SEM
Group I- Group II
6Ckine
15218.2 ± 4443.88
5247.1 ± 1557.9
0.0379
Axl
362.3 ± 221.5
241.9 ± 99.41
0.1718
BTC
2975.9 ± 1845.71
2713.4 ± 1146.08
0.7577
CCL28
509.2 ± 155.93
1615.4 ± 521.36
0.0675
CTACK/CCL27
501 ± 65.36
855.7 ± 343.16
0.6590
CXCL16
6974.2 ± 1614.47
6474.6 ± 675.76
0.6888
ENA-78/CXCL5
387.4 ± 83.7
1358.6 ± 460.2
0.6888
Eotaxin-3
2046 ± 1486.33
876.7 ± 206.93
0.9710
GCP-2
4039.6 ± 1086.68
5637.2 ± 1204.97
0.4064
GRO α, β, γ/CXCL1, CXCL2, CXCL3
All values below the range of quantification
213.3 ± 18.41
HCC-1/CCL14
830.4 ± 32.73
784.6 ± 213.38
0.3223
HCC-4/CCL16
356.2 ± 178.6
269.6 ± 73.05
0.7990
IL-9
189.7 ± 1572.82
658.6 ± 15762.47
0.0795
IL-17F
658.7 ± 51.63
658.6 ± 207.34
0.5549
IL-18 BPa
2336.6 ± 2052.55
3007.4 ± 1109.63
0.0823
IL-28A
62.9 ± 15.95
255.6 ± 74.43
0.1061
IL-29
1711.3 ± 417.42
4609.3 ± 1698.43
0.4698
IL-31
2001 ± 1490.36
479.8 ± 88.54
0.8125
IP-10/CXCL10
1284 ± 124.32
623.3 ± 130.48
0.0056
I-TAC/CXCL11
30.9 ± 9.21
103 ± 25.55
0.0097
LIF
707.7 ± 155.96
465.3 ± 161.85
0.1827
LIGHT/TNFSF14
45.6 ± 14.77
125.9 ± 30.51
0.0930
Lymphotactin/XCL1
483.8 ± 172.81
962.8 ± 212.61
0.2065
MCP-2/CCL8
8.6 ± 172.81
24.5 ± 5.07
0.0757
MCP-3/CCL7
16.6 ± 3.3
69.3 ± 17.73
0.0297
MCP-4/CCL13
572.7 ± 154.87
1197.1 ± 328.18
0.4940
MDC/CCL22
6979.1 ± 1134.39
8553.8 ± 1654.87
0.5357
MIF
987.5 ± 212.7
3213.2 ± 642.93
0.0052
MIP-3a (CCL20)
437.5 ± 220.5
705.8 ± 384.72
0.9131
MIP-3b/CCL19
55.2 ± 58.95
254.4 ± 89.81
0.7242
MPIF1/CCL23
1599.9 ± 471.2
684.8 ± 191.85
0.0379
MSPa
494.4 ± 116.29
1109.3 ± 242.83
0.0556
NAP-2/CXCL7
571.2 ± 40.21
374.2 ± 38.54
0.0048
OPN
26831.4 ± 2550.4
38045.8 ± 5993.53
0.3223
PARC/CCL18
Most of values below of range of quantification
534.5 ± 173.62
PF4
12437.2 ± 2184.23
23243.3 ± 4852.86
0.0556
SDF-1/CXCL12
1221.5 ± 345.75
1070.9 ± 265.25
0.5846
TARC/CCL17
6.5 ± 0.32
25.7 ± 9
TECK/CCL25
4700.2 ± 531.33
3998.8 ± 950.29
0.1101
TSLP
180.7 ± 79.67
250.9 ± 74.86
0.5600
Statistically significant value of less than 0.05 for Student’s -test. Statistically significant value of less than 0.05 for Mann-Whitney-Wilcoxon test.
