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Mediators of Inflammation
Volume 2014, Article ID 852378, 11 pages
http://dx.doi.org/10.1155/2014/852378
Research Article

Tumor Necrosis Factor Induces Developmental Stage-Dependent Structural Changes in the Immature Small Intestine

1Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
2Departments of Pediatrics and Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine and The Saban Research Institute at Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA

Received 13 June 2014; Revised 29 July 2014; Accepted 31 July 2014; Published 27 August 2014

Academic Editor: Ishak O. Tekin

Copyright © 2014 Kathryn S. Brown et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. J. McElroy and J. Weitkamp, “Innate immunity in the small intestine of the preterm infant,” NeoReviews, vol. 12, no. 9, pp. e517–e526, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Liu, L. Zhu, N. Y. Fatheree et al., “Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis,” The American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 297, no. 3, pp. G442–G450, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Du, M. Yang, S. Lee et al., “Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity,” Genes & Development, vol. 26, no. 12, pp. 1306–1311, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Neu and W. A. Walker, “Necrotizing enterocolitis,” The New England Journal of Medicine, vol. 364, no. 3, pp. 255–264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. S. C. Fitzgibbons, Y. Ching, D. Yu et al., “Mortality of necrotizing enterocolitis expressed by birth weight categories,” Journal of Pediatric Surgery, vol. 44, no. 6, pp. 1072–1076, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. J. C. Chandler and A. Hebra, “Necrotizing enterocolitis in infants with very low birth weight,” Seminars in Pediatric Surgery, vol. 9, no. 2, pp. 63–72, 2000. View at Google Scholar · View at Scopus
  7. R. F. Covert, J. Neu, M. J. Elliott, J. L. Rea, and P. A. Gimotty, “Factors associated with age of onset of necrotizing enterocolitis,” American Journal of Perinatology, vol. 6, no. 4, pp. 455–460, 1989. View at Publisher · View at Google Scholar · View at Scopus
  8. S. J. McElroy, M. A. Underwood, and M. P. Sherman, “Paneth cells and necrotizing enterocolitis: a novel hypothesis for disease pathogenesis,” Neonatology, vol. 103, no. 1, pp. 10–20, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. K. J. Tracey and A. Cerami, “Tumor necrosis factor, other cytokines and disease,” Annual Review of Cell Biology, vol. 9, pp. 317–343, 1993. View at Publisher · View at Google Scholar · View at Scopus
  10. P. W. Lin, T. R. Nasr, and B. J. Stoll, “Necrotizing enterocolitis: recent scientific advances in pathophysiology and prevention,” Seminars in Perinatology, vol. 32, no. 2, pp. 70–82, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. M. S. Caplan and W. Hsueh, “Necrotizing enterocolitis: role of platelet activating factor, endotoxin, and tumor necrosis factor,” Journal of Pediatrics, vol. 117, no. 1, part 2, pp. S47–S51, 1990. View at Publisher · View at Google Scholar · View at Scopus
  12. M. D. Halpern, J. A. Clark, T. A. Saunders et al., “Reduction of experimental necrotizing enterocolitis with anti-TNF-alpha,” The American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 290, no. 4, pp. G757–G764, 2006. View at Google Scholar
  13. S. J. McElroy, L. S. Prince, J. Weitkamp, J. Reese, J. C. Slaughter, and D. B. Polk, “Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis,” The American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 301, no. 4, pp. G656–G666, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. J. W. Arnold, G. R. Kimpel, and D. W. Niesel, “Tumor necrosis factor (TNFα) regulates intestinal mucus production during Salmonellosis,” Cellular Immunology, vol. 151, no. 2, pp. 336–344, 1993. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Spies, V. L. Chappell, M. R. Dasu, D. N. Herndon, J. C. Thompson, and S. E. Wolf, “Role of TNF-α in gut mucosal changes after severe burn,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 283, no. 3, pp. G703–G708, 2002. View at Google Scholar · View at Scopus
  16. S. J. McElroy, M. R. Frey, F. Yan et al., “Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 295, no. 2, pp. G285–G293, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. J. K. Bernard, S. P. McCann, V. Bhardwaj, M. K. Washington, and M. R. Frey, “Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo,” The Journal of Biological Chemistry, vol. 287, no. 47, pp. 39850–39858, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Zhang, M. P. Sherman, L. S. Prince et al., “Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice,” Disease Models and Mechanisms, vol. 5, no. 4, pp. 522–532, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. M. A. Underwood, “Paneth cells and necrotizing enterocolitis,” Gut Microbes, vol. 3, no. 6, pp. 562–565, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. C. L. Bevins and N. H. Salzman, “Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis,” Nature Reviews Microbiology, vol. 9, no. 5, pp. 356–368, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. D. G. Remick, R. G. Kunkel, J. W. Larrick, and S. L. Kunkel, “Acute in vivo effects of human recombinant tumor necrosis factor,” Laboratory Investigation, vol. 56, no. 6, pp. 583–590, 1987. View at Google Scholar · View at Scopus
  22. C. Rumio, M. Sommariva, L. Sfondrini et al., “Induction of Paneth cell degranulation by orally administered Toll-like receptor ligands,” Journal of Cellular Physiology, vol. 227, no. 3, pp. 1107–1113, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Bry, P. Falk, K. Huttner, A. Ouellette, T. Midtvedt, and J. I. Gordon, “Paneth cell differentiation in the developing intestine of normal and transgenic mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 22, pp. 10335–10339, 1994. View at Publisher · View at Google Scholar · View at Scopus
  24. M. I. Fernandez, B. Regnault, C. Mulet et al., “Maturation of paneth cells induces the refractory state of newborn mice to Shigella Infection,” Journal of Immunology, vol. 180, no. 7, pp. 4924–4930, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. R. A. Heller and M. Krönke, “Tumor necrosis factor receptor-mediated signaling pathways,” The Journal of Cell Biology, vol. 126, no. 1, pp. 5–9, 1994. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Loetscher, E. J. Schlaeger, H. Lahm, Y. E. Pan, W. Lesslauer, and M. Brockhaus, “Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells,” The Journal of Biological Chemistry, vol. 265, no. 33, pp. 20131–20138, 1990. View at Google Scholar · View at Scopus
  27. J. Corredor, F. Yan, C. C. Shen et al., “Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms,” The American Journal of Physiology—Cell Physiology, vol. 284, no. 4, pp. C953–C961, 2003. View at Google Scholar · View at Scopus
  28. W. H. Yee, A. S. Soraisham, V. S. Shah et al., “Incidence and timing of presentation of necrotizing enterocolitis in preterm infants,” Pediatrics, vol. 129, no. 2, pp. e298–e304, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. I. R. Sanderson, A. Walker, and NetLibrary, Development of the Gastrointestinal Tract, B. C. Decker, London, UK, 1999.
  30. P. Brandtzaeg, “The mucosal immune system and its integration with the mammary glands,” Journal of Pediatrics, vol. 156, no. 2, pp. S8–S15, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. H. B. Coutinho, H. Carmona Da Mota, V. B. Coutinho et al., “Absence of lysozyme (muramidase) in the intestinal Paneth cells of newborn infants with necrotising enterocolitis,” Journal of Clinical Pathology, vol. 51, no. 7, pp. 512–514, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. S. J. McElroy, S. L. Castle, J. K. Bernard et al., “The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis,” The American Journal of Pathology. In press.