TY - JOUR
A2 - Rodrigues, Mauricio Martins
AU - Sánchez-Arcila, Juan Camilo
AU - Perce-da-Silva, Daiana de Souza
AU - Vasconcelos, Mariana Pinheiro Alves
AU - Rodrigues-da-Silva, Rodrigo Nunes
AU - Pereira, Virginia Araujo
AU - Aprígio, Cesarino Junior Lima
AU - Lima, Cleoni Alves Mendes
AU - Fonseca, Bruna de Paula Fonseca e
AU - Banic, Dalma Maria
AU - Lima-Junior, Josué da Costa
AU - Oliveira-Ferreira, Joseli
PY - 2014
DA - 2014/09/16
TI - Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil
SP - 857245
VL - 2014
AB - In Brazil, malaria is prevalent in the Amazon region and these regions coincide with high prevalence of intestinal parasites but few studies explore the interaction between malaria and other parasites. Therefore, the present study evaluates changes in cytokine, chemokine, C-reactive protein, and nitric oxide (NO) concentrations in 264 individuals, comparing plasma from infected individuals with concurrent malaria and intestinal parasites to individuals with either malaria infection alone and uninfected. In the studied population 24% of the individuals were infected with Plasmodium and 18% coinfected with intestinal parasites. Protozoan parasites comprised the bulk of the intestinal parasites infections and subjects infected with intestinal parasites were more likely to have malaria. The use of principal component analysis and cluster analysis associated increased levels of IL-6, TNF-α, IL-10, and CRP and low levels of IL-17A predominantly with individuals with malaria alone and coinfected individuals. In contrast, low levels of almost all inflammatory mediators were associated predominantly with individuals uninfected while increased levels of IL-17A were associated predominantly with individuals with intestinal parasites only. In conclusion, our data suggest that, in our population, the infection with intestinal parasites (mainly protozoan) does not modify the pattern of cytokine production in individuals infected with P. falciparum and P. vivax.
SN - 0962-9351
UR - https://doi.org/10.1155/2014/857245
DO - 10.1155/2014/857245
JF - Mediators of Inflammation
PB - Hindawi Publishing Corporation
KW -
ER -