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Mediators of Inflammation
Volume 2014 (2014), Article ID 870634, 9 pages
Research Article

Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice

1Departamento de Biologia Celular e do Desenvolvimento, Universidade de São Paulo, Avenida Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil
2Programa de Pós-Graduação em Ciência da Motricidade, Departamento de Educação Física, Universidade Estadual Paulista (UNESP), 13506-900 Rio Claro, SP, Brazil
3Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-000 São Paulo, SP, Brazil
4Departamento de Ciências Biológicas, Laboratório de Movimento Humano da Universidade São Judas Tadeu, 05503-001 São Paulo, SP, Brazil
5Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-901 São Paulo, SP, Brazil
6Departamento de Fisiologia Geral, Instituto de Biociências, Universidade de São Paulo, 05508-090 São Paulo, SP, Brazil
7Programa de Pós-Graduação em Ciência do Movimento Humano, Instituto de Ciências da Atividade Física e Esporte, Universidade Cruzeiro do Sul, 01506-000 São Paulo, SP, Brazil

Received 25 April 2014; Revised 2 July 2014; Accepted 20 July 2014; Published 22 September 2014

Academic Editor: Fábio Santos Lira

Copyright © 2014 Edson A. Lima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Excess of saturated fatty acids in the diet has been associated with obesity, leading to systemic disruption of insulin signaling, glucose intolerance, and inflammation. Macadamia oil administration has been shown to improve lipid profile in humans. We evaluated the effect of macadamia oil supplementation on insulin sensitivity, inflammation, lipid profile, and adipocyte size in high-fat diet (HF) induced obesity in mice. C57BL/6 male mice (8 weeks) were divided into four groups: (a) control diet (CD), (b) HF, (c) CD supplemented with macadamia oil by gavage at 2 g/Kg of body weight, three times per week, for 12 weeks (CD + MO), and (d) HF diet supplemented with macadamia oil (HF + MO). CD and HF mice were supplemented with water. HF mice showed hypercholesterolemia and decreased insulin sensitivity as also previously shown. HF induced inflammation in adipose tissue and peritoneal macrophages, as well as adipocyte hypertrophy. Macadamia oil supplementation attenuated hypertrophy of adipocytes and inflammation in the adipose tissue and macrophages.