Cytomegalovirus Infection Impairs Immunosuppressive and Antimicrobial Effector Functions of Human Multipotent Mesenchymal Stromal Cells
Figure 2
Influence of MSC and CMV on T-cell proliferation. (a) PBL were cultured in the absence or presence of CMV (corresponding to MOI 5) for three days and were stimulated with OKT3 or not. Data are given as mean cpm [3H] thymidine incorporation of four independent experiments with cells from different donors. (b) PBL were cultured in the presence of MSC (3 × 104/well) and in the absence or presence of 1-MT (1.5 mM) or CMV (MOI 5). T-cell proliferation was determined as described above. Data are given as % of positive control (OKT3-activated PBL without MSC). The significant inhibition of T-cell proliferation by MSC is marked with one asterisk (); the significant antagonistic effect on T-cell inhibition by CMV or 1MT is marked with two asterisks ().
