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Mediators of Inflammation
Volume 2014 (2014), Article ID 908901, 6 pages
Research Article

Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation

1Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, Italy
2Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
3Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological, and Geriatric Sciences, Policlinico Umberto, Sapienza University of Rome, 00161 Rome, Italy
4Department of AngioCardioNeurology, IRCCS NeuroMed, 86077 Pozzilli, Italy

Received 25 December 2013; Accepted 20 January 2014; Published 26 February 2014

Academic Editor: M. M. Corsi Romanelli

Copyright © 2014 Roberto Carnevale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Adiponectin (APN) possesses anti-inflammatory and antiatherogenic effects. Atrial fibrillation (AF) is burdened by enhanced systemic inflammation and platelet activation, as documented by increased blood levels of soluble CD40L (sCD40L). The interplay between APN and platelet activation in AF is still undefined. Materials and Methods. Circulating levels of APN and sCD40L were measured in 257 anticoagulated nonvalvular AF patients. Exclusion criteria were as follows: prosthetic heart valves, cardiac revascularization in the previous year, severe cognitive impairment, chronic infectious or autoimmune diseases, and active cancer. Results. Mean age was 72.9 (±8.7) years and 41.6% were female. Serum APN and plasmatic sCD40L were inversely correlated ( −0.626, ). A progressive increase of sCD40L across tertiles of CHA2DS2-VASc score was observed (rS 0.473, ), whilst APN was inversely correlated (rS −0.463,  ). A multivariable linear regression analysis showed that CHA2DS2-VASc score ( −0.227, ) and sCD40L ( −0.524, ) correlated to APN. Conclusions. AF patients at high risk of stroke disclose low and high levels of APN and sCD40L, respectively, suggesting a role for APN if it favors platelet activation in vivo in this clinical setting. Enhancing APN levels may be a future goal to reduce the risk of vascular outcomes in AF patients.