Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma

Figure 3

Immunohistochemical staining of normal and cancerous ovarian tissues for IL-18, IL-18R, and IL-18BP. Immunohistochemical staining of normal ((a), (f), (k)) and different types of cancerous ovarian tissues: serous papillary ((b), (g), (l)), mucinous ((c), (h), (m)), and endometrioid ((d), (i), (n)) with mouse anti-human IL-18 ((a)–(d)), mouse anti-human IL-18R ((f)–(i)), and goat anti-human IL-18BP ((k)–(n)) antibodies. Both normal (j) and cancerous ((e), (o)) tissues were used as negative control. EP: epithelial cells and S: stroma. Magnification: ×600.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)

(m)

(n)

(o)