Mediators of Inflammation

Clinical Study

Metabolic and Genetic Screening of Electromagnetic Hypersensitive Subjects as a Feasible Tool for Diagnostics and Intervention

Table 1

Statistical analysis of genotype distribution of cytochrome P450 (CYP) isoenzymes in EHS-patients self-reporting electromagnetic hypersensitivity ( ) versus MCS-multiple chemical sensitivity patients without EHS ( ) and of glutathione S-transferase P1 (GSTP1), glutathione S-transferase M1 (GSTM1), and glutathione S-transferase T1 (GSTT1) isoenzymes in CTR-healthy control subjects ( ) versus EHS-patients ( ).
GenotypeCTREHSMCS Odds RatioC.I. 95%
CYP2C19 (*1/*1) 26 (89.7%)51 (60.0%) 0.003  
CYP2C19 (*1/*2, *2/*2) 3 (6.9%)34 (38.8%)  
GSTP1 (*A/*A, *A/*B)62 (91%)104 (82%)  0.09
n.s.
GSTP1 (*B/*B, *B/*C, *C/*C, *A/*C) 6 (9%)23 (18%) 
GSTM1 (*1/*1, *1/*0)36 (53%)64 (50%)  n.s.
GSTM1 (*0/*0)32 (47%)63 (50%) 
GSTT1 (*1/*1, *1/*0)58 (85%)101 (80%)  n.s.
GSTT1 (*0/*0)10 (15%)26 (20%) 
GSTM1 (*1/*1, *1/*0) + GSTT1 (*1/*1, *1/*0)67 (98.5%) 111 (87%)   0.0079.7(1.3–74.5)
GSTM1 (*0/*0) + GSTT1 (*0/*0)1 (1.5%)16 (13%)