Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome

Table 2

Inflammatory markers of non-ST-segment elevation acute coronary syndrome patients with and without MACE at 36-month followup.

Variable	MACE		P value
	Yes; (𝑛=45)	No; (𝑛=210)
hsCRP at admission (mg/L)	7.4 [2.4–10.5]	7.4 [2.8–18.2]	0.79
hsCRP at 36-month followup (mg/L)	23 [10.4–34.7]	18.3 [7.3–26.6]	0.07
Delta hsCRP (mg/L)	15.5 [−28.7–73.3]	7.5 [−57.9–65.0]	0.01
GDF-15 at admission (pg/mL)	1639 [833–3151]	2190 [1333–3484]	0.09
GDF-15 at 36 months (pg/mL)	9105 [8071–9766]	3203 [2064–4572]	<0.001
Delta GDF-15 (pg/mL)	7605 [4831–8155]	602 [−405–2278]	<0.001

Data are expressed as median [interquartile range].
MACE: major adverse cardiovascular events; hsCRP: high-sensitivity C-reactive protein and GDF-15: growth-differentiation factor-15.