Myeloid Knockout of HIF-1 α Does Not Markedly Affect Hemorrhage/Resuscitation-Induced Inflammation and Hepatic Injury

Figure 1

Schematic timeline of the experimental design (a). Blue line denotes the mean arterial blood pressure (MABP) before, during, and after hemorrhage and resuscitation. (b) Mean arterial blood pressure was measured before hemorrhagic shock and at different times during the hemorrhage/resuscitation protocol in wild-type (WT, 𝑛=8) and HIF-1α knockout mice (KO, 𝑛=12). (c)-(d) Hepatic gene expressions of vegf (c) and adm (d) were analyzed. Gene expression was measured as fold change compared to 18srRNA expression (^∗𝑃<0.05 versus all other groups).

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