Mediators of Inflammation / 2014 / Article / Fig 3

Research Article

Leukocyte Production of Inflammatory Mediators Is Inhibited by the Antioxidants Phloretin, Silymarin, Hesperetin, and Resveratrol

Figure 3

Production of the chemokines CCL2, CCL5, MIP-1α, MIP-1β, and CXCL5. Human PBMCs were cultured for 18 hrs in media alone, stimulated with Aa Y4 LPS (1 μg/mL), or treated with Phloretin, Silymarin, Hesperetin, or Resveratrol at a concentration of  M for 2 hrs prior to, and throughout, stimulation. After 18 hrs, the concentrations of (a) CCL2, (b) CCL5, (c) MIP-1α, (d) MIP-1β, and (e) CXCL5, were assayed by cytometric bead array. ANOVA was performed for statistical analysis, indicating statistical significance versus LPS. #Outside of range (above), independent donors.
938712.fig.003a
(a)
938712.fig.003b
(b)
938712.fig.003c
(c)
938712.fig.003d
(d)
938712.fig.003e
(e)

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.