Untangling the Web of Systemic Autoinflammatory Diseases

Figure 1

Anteroposterior radiograph performed in a 12-year-old boy with chronic infantile neurological cutaneous and articular (CINCA) syndrome, showing a calcified mass-like region in the physis of the distal femur (see white arrows). Osteoarthropathy of CINCA patients is a unique feature of this condition, caused by abnormal endochondral bone growth, mainly affecting large joints and long bones, beginning in the first infancy and causing striking changes until skeletal maturity.