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Mediators of Inflammation
Volume 2014, Article ID 954502, 14 pages
http://dx.doi.org/10.1155/2014/954502
Research Article

Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-1 Expression and Autophagy

Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, China

Received 4 November 2013; Revised 16 February 2014; Accepted 25 February 2014; Published 17 April 2014

Academic Editor: Sunil Kumar Manna

Copyright © 2014 Miao Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. A. Wynn, “Cellular and molecular mechanisms of fibrosis,” Journal of Pathology, vol. 214, no. 2, pp. 199–210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Kisseleva and D. A. Brenner, “Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis,” Journal of Gastroenterology and Hepatology, vol. 22, no. 1, pp. S73–S78, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. J. X. Jiang and N. J. Torok, “Liver injury and the activation of the hepatic myofibroblasts,” Current Pathobiology Reports, vol. 1, no. 3, pp. 215–223, 2013. View at Google Scholar
  4. F. Tacke and R. Weiskirchen, “Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques,” Expert Review of Gastroenterology and Hepatology, vol. 6, no. 1, pp. 67–80, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Baghy, R. V. Iozzo, and I. Kovalszky, “Decorin-TGFbeta axis in hepatic fibrosis and cirrhosis,” Journal of Histochemistry & Cytochemistry, vol. 60, no. 4, pp. 262–268, 2012. View at Google Scholar
  6. W. R. Bi, C. Q. Yang, and Q. Shi, “Transforming growth factor-beta1 induced epotheial-mesenchymal transition in hepatic fibrosis,” Hepatogastroenterology, vol. 59, no. 118, pp. 1960–1963, 2012. View at Google Scholar
  7. M. D. Sentíes-Gómez, F. J. Gálvez-Gastélum, E. Meza-García, and J. Armendáriz-Borunda, “Hepatic fibrosis: role of matrix metalloproteases and TGFbeta1,” Gaceta Médica de México, vol. 141, no. 4, pp. 315–322, 2005. View at Google Scholar
  8. M. J. P. Arthur, “Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis,” The American Journal of Physiology, vol. 279, no. 2, pp. G245–G249, 2000. View at Google Scholar · View at Scopus
  9. V. Hernndez-Gea, Z. Ghiassi-Nejad, R. Rozenfeld et al., “Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues,” Gastroenterology, vol. 142, no. 4, pp. 938–946, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. L. F. R. Thoen, E. L. M. Guimarães, L. Dollé et al., “A role for autophagy during hepatic stellate cell activation,” Journal of Hepatology, vol. 55, no. 6, pp. 1353–1360, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. L. F. R. Thoen, E. L. Guimarães, and L. A. van Grunsven, “Autophagy: a new player in hepatic stellate cell activation,” Autophagy, vol. 8, no. 1, pp. 126–128, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. A. M. Choi, S. W. Ryter, and B. Levine, “Autophagy in human health and disease,” The New England Journal of Medicine, vol. 368, no. 7, pp. 651–662, 2013. View at Google Scholar
  13. R. Kang, H. J. Zeh, M. T. Lotze, and D. Tang, “The Beclin 1 network regulates autophagy and apoptosis,” Cell Death and Differentiation, vol. 18, no. 4, pp. 571–580, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Murrow and J. Debnath, “Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease,” Annual Review of Pathology, vol. 8, pp. 105–137, 2013. View at Google Scholar
  15. M. Harada, “Autophagy in liver diseases,” Journal of UOEH, vol. 33, no. 4, pp. 337–344, 2011. View at Google Scholar · View at Scopus
  16. L. Jie, W. Fan, D. Weiqi et al., “The Hippo-YES association protein pathway in liver cancer,” Gastroenterology Research and Practice, vol. 2013, Article ID 187070, 7 pages, 2013. View at Publisher · View at Google Scholar
  17. G. Hussein, U. Sankawa, H. Goto, K. Matsumoto, and H. Watanabe, “Astaxanthin, a carotenoid with potential in human health and nutrition,” Journal of Natural Products, vol. 69, no. 3, pp. 443–449, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Higuera-Ciapara, L. Félix-Valenzuela, and F. M. Goycoolea, “Astaxanthin: a review of its chemistry and applications,” Critical Reviews in Food Science and Nutrition, vol. 46, no. 2, pp. 185–196, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Hashimoto, K. Arai, Y. Obara et al., “Effects of astaxanthin on antioxidation in human aqueous homor,” Journal of Clinical Biochemistry and Nutrition, vol. 53, no. 1, pp. 1–7, 2013. View at Google Scholar
  20. J.-O. Kang, S.-J. Kim, and H. Kim, “Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl4-treated rats,” Methods and Findings in Experimental and Clinical Pharmacology, vol. 23, no. 2, pp. 79–84, 2001. View at Google Scholar · View at Scopus
  21. G. D. Curek, A. Cort, G. Yucel et al., “Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion,” Toxicology, vol. 267, no. 1–3, pp. 147–153, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Kavitha, J. Kowshik, T. K. Kishore, A. B. Baba, and S. Nagini, “Astaxanthin inhibits NF-kappa B and Wnt/beta-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in hamster model of oral cancer,” Biochimica et Biophysica Acta, vol. 1830, no. 10, pp. 4433–4444, 2013. View at Google Scholar
  23. M. Wang, J. Zhang, and C. Lv, “Astaxanthin ameliorates lung fibrosis in vivo and in vitro by preventing trasdifferentiation, inhibiting proliferation, and promoting apoptosis of activated cells,” Food and Chemical Toxicology, vol. 56, pp. 450–458, 2013. View at Google Scholar
  24. C. Xie, M. Meng, X. Yin, F. He, H. Ye, and D. Xie, “Effects of astaxanthin on renal fibrosis and cell apoptosis induced by partial unilateral ureteral obstruction in rats,” Nan Fang Yi Ke Da Xue Xue Bao, vol. 33, no. 2, pp. 305–308, 2013. View at Google Scholar
  25. V. Sanchez-Valle, M. Uribe, N. Mendez-Sanchez et al., “Role of oxidative stress and molecular changes in liver fiborsis: review,” Current Medicinal Chemistry, vol. 19, no. 28, pp. 4850–4860, 2012. View at Google Scholar
  26. J. A. Fallowfield, “Therapeutic targets in liver fibrosis,” The American Journal of Physiology, vol. 300, no. 5, pp. G709–G715, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. J. P. Iredale, “Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ,” Journal of Clinical Investigation, vol. 117, no. 3, pp. 539–548, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Shen, J. Lu, P. Cheng et al., “Ethyl pyruvate pretreatment attenuates concanavalin A-induced autoimmune hepatitis in mice,” PLos ONE, vol. 9, no. 2, Article ID e87977, 2014. View at Publisher · View at Google Scholar
  29. S. L. Friedman, “Mechanisms of Hepatic Fibrogenesis,” Gastroenterology, vol. 134, no. 6, pp. 1655–1669, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Sunami, F. Leithauser, T. Wirth et al., “Hepatic activation of IKK/NF-kappa B signaling induces liver fibrosis via macrophage-mediated chronic inflammation,” Hepatology, vol. 56, no. 3, pp. 1117–1128, 2012. View at Google Scholar
  31. W. W. Li, Q. C. Wang, L. J. Hou et al., “Correlation of the expression of NF-kappa B p65 and hepatic fibrosis in hepatitis patients,” Zhonghua Yi Xue Za Zhi, vol. 92, no. 27, pp. 1886–1888, 2012. View at Google Scholar
  32. S.-J. Lee, S.-K. Bai, K.-S. Lee et al., “Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing IκB kinase-dependent NF-κB activation,” Molecules and Cells, vol. 16, no. 1, pp. 97–105, 2003. View at Google Scholar · View at Scopus
  33. Y. Suzuki, K. Ohgami, K. Shiratori et al., “Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-κB signaling pathway,” Experimental Eye Research, vol. 82, no. 2, pp. 275–281, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. Y.-P. Han, “Matrix metalloproteinases, the pros and cons, in liver fibrosis,” Journal of Gastroenterology and Hepatology, vol. 21, no. 3, pp. S88–S91, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. E. A. Oczypok, T. D. Oury, and C. T. Chu, “It’s a cell-eat-cell world: autophagy and phagocytosis,” The American Journal of Patholog, vol. 182, no. 3, pp. 612–622, 2013. View at Google Scholar
  36. Y. Q. Zhou, W. Dai, C. Y. Guo et al., “Protective effects of necrostatin-1 in concanavalin A-induced acute hepatic injury in mice,” Mediators of Inflammation, vol. 2013, Article ID 706156, 15 pages, 2013. View at Publisher · View at Google Scholar
  37. M. Shen, J. Lu, W. Dai et al., “Ethyl pyruvate ameliorates hepatic ischemia-reperfusion injury by inhibiting intrinsic pathway of apoptosis and autophagy,” Mediators of Inflammation, vol. 2013, Article ID 461536, 12 pages, 2013. View at Publisher · View at Google Scholar
  38. S. I. Kim, H.-J. Na, Y. Ding, Z. Wang, S. J. Lee, and M. E. Choi, “Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-β1,” The Journal of Biological Chemistry, vol. 287, no. 15, pp. 11677–11688, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Ding, J. K. Kim, S. I. Kim et al., “TGF-β1 protects against mesangial cell apoptosis via induction of autophagy,” The Journal of Biological Chemistry, vol. 285, no. 48, pp. 37909–37919, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Gajewska, B. Gajkowska, and T. Motyl, “Apoptosis and autophagy induced by TGF-β1 in bovine mammary epithelial BME-UV1 cells,” Journal of Physiology and Pharmacology, vol. 56, supplement 3, pp. 143–157, 2005. View at Google Scholar · View at Scopus