A Novel Chemically Modified Curcumin Reduces Severity of Experimental Periodontal Disease in Rats: Initial Observations
Direct measurements on defleshed hemimaxillae demonstrate that CMC 2.24 significantly inhibits alveolar bone resorption in the in vivo model of LPS-induced periodontal disease. The bar graph presents the results of the percent of exposed root surface, which is directly proportional to the extent of bone loss, according to the experimental group. LPS caused bone loss as indicated by the significant increase of the area of exposed root surface, whereas simultaneous systemic administration of CMC 2.24 significantly reduced this area, indicating an attenuation of inflammatory-driven bone resorption. Differences between experimental conditions are indicated by the brackets and (unpaired -test for independent samples with Welch’s correction for unequal variances).