Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2014 (2014), Article ID 967205, 6 pages
http://dx.doi.org/10.1155/2014/967205
Research Article

Alleviation of Antioxidant Defense System by Ozonized Olive Oil in DNBS-Induced Colitis in Rats

1Department of Pharmacology and Toxicology, Dubai Pharmacy College, P.O. Box 19099, Dubai, UAE
2Department of Pathology, Dubai Medical College, Dubai, UAE
3Department of Pharmaceutical Chemistry and Natural Products, Dubai Pharmacy College, Dubai, UAE

Received 22 July 2014; Accepted 6 August 2014; Published 4 September 2014

Academic Editor: Vinod K. Mishra

Copyright © 2014 Eman Abu-Gharbieh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Abeck and S. Plötz, “Colloidal silver and ozonized olive oil for atopic dermatitis?” Medizinische Monatsschrift fur Pharmazeuten, vol. 31, no. 7, pp. 265–266, 2008. View at Google Scholar · View at Scopus
  2. F. Sakazaki, H. Kataoka, T. Okuno et al., “Ozonated olive oil enhances the growth of granulation tissue in a mouse model of pressure ulcer,” Ozone: Science and Engineering, vol. 29, no. 6, pp. 503–507, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Matsumoto, S. Sakurai, N. Shinriki, S. Suzuk, and T. Miura, “Therapeutic effects of ozonized olive oil in the treatment of intractable fistula and wound after surgical operation,” Journal of Japan Surgical Association, vol. 61, pp. 1383–1389, 2000. View at Google Scholar
  4. Y. Kagawa, Standard Tables of Food Composition in Japan, Joshi Eiyou Daigaku, Tokyo, Japan, 2001.
  5. R. Criegee, “Mechanism of ozonolysis,” Angewandte Chemie—International Edition, vol. 14, no. 11, pp. 745–752, 1975. View at Google Scholar
  6. T. Miura, A. Iwai, K. Tamoto, A. Yamazaki, and H. Nochi, “Components and ant-inflammatory action mechanism of ozonized olive oil,” in Proceeding of the 19th Ozone World Congress of the IOA, pp. 145–166, Tokyo, Japan, 2014.
  7. S. Schulz, “A new model for integral measuring of wound healing processes in small laboratory animals, tested with ozonized olive oil,” Deutsche Tierarztliche Wochenschrift, vol. 88, no. 2, pp. 60–64, 1981. View at Google Scholar · View at Scopus
  8. S. Sakurai, “Physicochemical property and clinical application of ozonated olive oil,” Pharm Tech Japan, vol. 17, no. 11, pp. 1791–1800, 2001. View at Google Scholar
  9. “Standard practice for testing biomaterials in rabbits for primary skin irritation,” ASTM F719-81, ASTM, West Conshohocken, Pa, USA, 2007.
  10. Pharmaceutical Society of Japan, Standard Methods of Analysis for Hygienic Chemists, Kanehara Shuppan Co., Tokyo, Japan, 1995.
  11. V. Vasina, E. Abu-Gharbieh, G. Barbara et al., “The β3-adrenoceptor agonist SR58611A ameliorates experimental colitis in rats,” Neurogastroenterology and Motility, vol. 20, no. 9, pp. 1030–1041, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Publisher · View at Google Scholar · View at Scopus
  13. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, “Protein measurement with the Folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Google Scholar · View at Scopus
  14. M. L. Harris, H. J. Schiller, P. M. Reilly, M. Donowitz, M. B. Grisham, and G. B. Bulkley, “Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: cause, consequence or epiphenomenon?” Pharmacology & Therapeutics, vol. 53, no. 3, pp. 375–408, 1992. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Van der Vliet and A. Bast, “Role of reactive oxygen species in intestinal diseases,” Free Radical Biology and Medicine, vol. 12, no. 6, pp. 499–513, 1992. View at Publisher · View at Google Scholar · View at Scopus
  16. M. B. Grisham and D. N. Granger, “Neutrophil-mediated mucosal injury: role of reactive oxygen metabolites,” Digestive Diseases and Sciences, vol. 33, no. 3, pp. 6S–15S, 1988. View at Google Scholar · View at Scopus
  17. S. Cuzzocrea, B. Zingarelli, P. Hake, A. L. Salzman, and C. Szabo, “Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation,” Free Radical Biology and Medicine, vol. 24, no. 3, pp. 450–459, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Keshavarzian, G. Morgan, S. Sedghi, J. H. Gordon, and M. Doria, “Role of reactive oxygen metabolites in experimental colitis,” Gut, vol. 31, no. 7, pp. 786–790, 1990. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Seguí, M. Gironella, M. Sans et al., “Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine,” Journal of Leukocyte Biology, vol. 76, no. 3, pp. 537–544, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. J. V. Hawkins, E. L. Emmel, J. J. Feuer et al., “Protease activity in a hapten-induced model of ulcerative colitis in rats,” Digestive Diseases and Sciences, vol. 42, no. 9, pp. 1969–1980, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Nieto, M. I. Fernandez, M. I. Torres, A. Ríos, M. D. Suarez, and A. Gil, “Dietary monounsaturated n-3 and n-6 long-chain polyunsaturated fatty acids affect cellular antioxidant defense system in rats with experimental ulcerative colitis induced by trinitrobenzene sulfonic acid,” Digestive Diseases and Sciences, vol. 43, no. 12, pp. 2676–2687, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Halliwell, “Reactive oxygen species in living systems: source, biochemistry, and role in human disease,” The American Journal of Medicine, vol. 91, no. 3, pp. 14S–22S, 1991. View at Google Scholar · View at Scopus
  23. B. Halliwell, “Reactive oxygen species and the central nervous system,” Journal of Neurochemistry, vol. 59, no. 5, pp. 1609–1623, 1992. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Loguercio, G. D'Argenio, M. Delle Cave et al., “Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats,” Digestive Diseases and Sciences, vol. 41, no. 6, pp. 1204–1211, 1996. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. B. Zamora Rodríguez, R. González Álvarez, D. Guanche et al., “Antioxidant mechanism is involved in the gastroprotective effects of ozonized sunflower oil in ethanol-induced ulcers in rats,” Mediators of Inflammation, vol. 2007, Article ID 65873, 6 pages, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. P. S. Bailey, Ozonation in Organic Chemistry, Academic Press, New York, NY, USA, 1978.
  27. M. Díaz, I. Lezcano, J. Molerio, and F. Hernández, “Spectroscopic characterization of ozonides with biological activity,” Ozone: Science & Engineering, vol. 23, no. 1, pp. 35–40, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. N. S. I. Geweely, “Antifungal activity of ozonized olive oil (Oleozone),” International Journal of Agriculture and Biology, vol. 8, no. 5, pp. 670–675, 2006. View at Google Scholar
  29. D. Bilici, H. Süleyman, Z. N. Banoglu et al., “Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect,” Digestive Diseases and Sciences, vol. 47, no. 4, pp. 856–861, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Kanter, H. Demir, C. Karakaya, and H. Ozbek, “Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats,” World Journal of Gastroenterology, vol. 11, no. 42, pp. 6662–6666, 2005. View at Google Scholar · View at Scopus